間質流によって生み出される細胞集団のかたち

• 須藤 亮

  慶應義塾大学理工学部システムデザイン工学科

書誌事項

タイトル別名

• Multi-cellular Morphogenesis Derived by Interstitial Flow
• カンシツリュウ ニ ヨッテ ウミダサレル サイボウ シュウダン ノ カ タチ

抄録

Biomechanical stimuli derived by interstitial flow regulate morphogenesis of multicellular systems including both physiological and pathological cells. For example, hepatocytes construct three-dimensional structures in directional interstitial flow conditions. Protrusions of tumor cells are also induced by interstitial flow, resulting in enhanced tumor cell invasion. Interestingly, the direction of tumor cell invasion in response to directional interstitial flow differs depending on the type of tumor cells. Furthermore, endothelial cells form capillary networks against the direction of interstitial flow in a magnitude-dependent manner. Taken together, interstitial flow is an important factor for regulating morphogenesis of multicellular systems.

収録刊行物

• 生物物理

  生物物理 60 (1), 025-030, 2020

  一般社団法人 日本生物物理学会

キーワード

• interstitial flow
• microfluidic device
• 3D culture

詳細情報

• CRID: 1390002184869326592
• NII論文ID: 130007790187
• NII書誌ID: AN00129693
• DOI: 10.2142/biophys.60.025
• ISSN: 13474219
• ISSN: 05824052
• NDL書誌ID: 030261530
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I030261530
• Web Site: https://www.jstage.jst.go.jp/article/biophys/60/1/60_025/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2020197089
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
  • KAKEN
• 抄録ライセンスフラグ: 使用不可