Suppression of the pathogenicity of <i>Candida albicans</i> by the quorum-sensing molecules farnesol and tryptophol
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- Singkum Pantira
- Department of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University
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- Muangkaew Watcharamat
- Department of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University
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- Suwanmanee San
- Department of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University
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- Pumeesat Potjaman
- Department of Medical Technology, Faculty of Science and Technology, Bansomdejchaopraya Rajabhat University
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- Wongsuk Thanwa
- Department of Clinical Pathology, Faculty of Medicine, Vajira Hospital, Navamindradhiraj University
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- Luplertlop Natthanej
- Department of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University
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抄録
<p>This study examines the ability of the quorum-sensing molecules (QSMs) farnesol and tryptophol to induce programmed cell death of the pathogenic fungus Candida albicans, to alter the expression of apoptosis-related genes, and to reduce the pathogenicity and virulence of C. albicans in Galleria mellonella. Our results showed that both farnesol and tryptophol inhibited C. albicans germ tube formation. In the QSM-treated group, the expression levels of the apoptosis genes increased, whereas the expression level of the anti-apoptosis gene decreased. Further, pretreatment of C. albicans with tryptophol or farnesol prior to G. mellonella larval infection significantly enhanced host survival compared with larvae infected with untreated C. albicans. Thus, farnesol and tryptophol may trigger apoptosis of C. albicans in vitro and reduce the virulence of C. albicans in vivo. Although further study is needed to identify the precise mechanisms underlying the antifungal properties of farnesol and tryptophol, these results suggest that QSMs may be effective agents for controlling fungal infection.</p>
収録刊行物
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- The Journal of General and Applied Microbiology
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The Journal of General and Applied Microbiology 65 (6), 277-283, 2019
公益財団法人 応用微生物学・分子細胞生物学研究奨励会