Experimental Study with Regard to the Effects of Energy Titration of the Laserballoon on the Lesion Creation Using Porcine Myocardium
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- Okishige Kaoru
- Heart Center, Japan Red Cross Yokohama City Bay Hospital
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- Shigeta Takatoshi
- Heart Center, Japan Red Cross Yokohama City Bay Hospital
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- Nakamura Rena A.
- Heart Center, Japan Red Cross Yokohama City Bay Hospital
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- Hirao Tatsuhiko
- Heart Center, Japan Red Cross Yokohama City Bay Hospital
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- Yoshida Hiroshi
- Heart Center, Japan Red Cross Yokohama City Bay Hospital
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- Oda Atsuhito
- Heart Center, Japan Red Cross Yokohama City Bay Hospital
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- Yamauchi Yasuteru
- Heart Center, Japan Red Cross Yokohama City Bay Hospital
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- Sasano Tetsuo
- Arrhythmia Center, Tokyo Medical and Dental University
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- Hirao Kenzo
- Arrhythmia Center, Tokyo Medical and Dental University
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抄録
<p>Laserballoon-based pulmonary vein isolation has proven to be safe and effective. However, the influence of the laser energy titration on the lesion formation has never been fully investigated. The aim of this study was to determine the relationship between the delivered laser energy and lesion size, as well as the incidence of steam pop.</p><p>The whole porcine heart was excised, and the left ventricular myocardium was separated into four specimens. Myocardial specimens were embedded in a warm mattress to keep the myocardial temperature around 37°C. The laserballoon was located so that the surface of the laserballoon was attached to the myocardium. The laser energy was irradiated against the surface of myocardium at 5.5, 8.5, 10.0, and 12.0 W for 3, 5, 10, and 20 seconds. The depth, surface area, and lesion volume were measured using a digital vernier caliper.</p><p>At constant laser energy and time, the lesion size increased significantly with the increasing energy (P < 0.001) and application duration (P < 0.001). The steam pop was provoked when a 12.0 W laser energy was applied for longer than 16 seconds, and it occurred in 2 out of 8 lesions.</p><p>The laserballoon demonstrated the ability to create a lesion formation in a dose- and time-dependent manner. Steam pop could be provoked with high-energy irradiation.</p>
収録刊行物
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- International Heart Journal
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International Heart Journal 61 (1), 121-127, 2020-01-31
一般社団法人 インターナショナル・ハート・ジャーナル刊行会