MALDI Mass Spectrometry of Small Molecules Using Nanometer-sized Clay

• XU Jiawei

  Department of Applied Chemistry, Graduate School of Science and Engineering, Toyo University Bio-Nano Electronics Research Centre, Toyo University

• KONDO Junko N.

  Laboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology

• FUJINO Tatsuya

  Department of Applied Chemistry, Graduate School of Science and Engineering, Toyo University Bio-Nano Electronics Research Centre, Toyo University

抄録

Nanometer-sized clay, allophane, was used as the matrix for matrix-assisted laser desorption ionization mass spectrometry (MALDI MS) and applied to the ionization of small molecules. First, the laser desorption ionization mass spectrum of cation-exchanged allophane was measured, and it was found that the cation exchange proceeded smoothly with increasing atomic number of alkali metals in the periodic table. This phenomenon was explained by considering the size of the counter anion on the allophane surface. Then, fructose was measured as the analyte using each alkali-cation-exchanged allophane as the matrix. Contrary to the measurements using allophane itself, the peak intensity of fructose decreased with increasing atomic number of alkali metals in the periodic table. This phenomenon was clarified by considering the stability of alkali cation in the presence of a surface anion, the desorption energy, and the solvation enthalpy of each alkali cation. The applicability of allophane to high molecular weight compounds was also confirmed by measuring cyclodextrin, angiotensin II, and insulin. Finally, a combination of allophane and zeolite was examined by assuming proton relay among allophane, zeolite, and analyte. As a result of proton supply from zeolite to allophane, the peak intensity of the proton sponge (1,8-bis(dimethylamino)naphthalene) was enhanced by almost 2.2 times.

収録刊行物

• Analytical Sciences

  Analytical Sciences 36 (2), 177-181, 2020-02-10

  社団法人 日本分析化学会

キーワード

• Allophane
• MALDI
• nano
• zeolite

詳細情報

• CRID: 1390565134827024384
• NII論文ID: 130007796073
• NII書誌ID: AA10500785
• DOI: 10.2116/analsci.19p213
• ISSN: 13482246
• ISSN: 09106340
• NDL書誌ID: 030249654
• PubMed: 31474660
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I030249654
• Web Site: https://link.springer.com/content/pdf/10.2116/analsci.19P213.pdf
• Web Site: https://link.springer.com/article/10.2116/analsci.19P213/fulltext.html
• Web Site: https://www.jstage.jst.go.jp/article/analsci/36/2/36_19P213/_pdf
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
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