Cell density-dependent modulation of perlecan synthesis by dichloro(2,9-dimethyl-1,10-phenanthroline)zinc(II) in vascular endothelial cells

• Hara Takato

  Faculty of Pharmaceutical Sciences, Toho University

• Sakamaki Sayaka

  Faculty of Pharmaceutical Sciences, Toho University

• Ikeda Atsuya

  Faculty of Pharmaceutical Sciences, Toho University

• Nakamura Takehiro

  Faculty of Pharmacy, Kindai University

• Yamamoto Chika

  Faculty of Pharmaceutical Sciences, Toho University

• Kaji Toshiyuki

  Faculty of Pharmaceutical Sciences, Tokyo University of Science

抄録

Proteoglycans that are synthesized by vascular endothelial cells contribute to the proliferation, migration, and blood coagulation-fibrinolytic system in vascular endothelial cells. Clarification of the molecular mechanisms for proteoglycan synthesis allows understanding of the regulation of endothelial functions. The research strategy of bioorganometallics analyzes biological systems using organic-inorganic hybrid molecules as tools. The present study found dichloro(2,9-dimethyl-1,10-phenanthroline)zinc(II) and its ligand-modulated perlecan expression in vascular endothelial cells, which depends on the cell density.

収録刊行物

• Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｔｏｘｉｃｏｌｏｇｉｃａｌ　Ｓｃｉｅｎｃｅｓ

  Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｔｏｘｉｃｏｌｏｇｉｃａｌ　Ｓｃｉｅｎｃｅｓ 45 (2), 109-115, 2020

  一般社団法人　日本毒性学会

キーワード

• Bioorganometallics
• Proteoglycan
• Perlecan
• Vascular endothelial cell
• Zinc complex
• 2,9-Dimethyl-1,10-phenathroline

詳細情報

• CRID: 1390002184875606144
• NII論文ID: 130007798450
• NII書誌ID: AN00002808
• DOI: 10.2131/jts.45.109
• ISSN: 18803989
• ISSN: 03881350
• NDL書誌ID: 030384448
• PubMed: 32062617
• Web Site: http://id.ndl.go.jp/bib/030384448
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I030384448
• Web Site: https://www.jstage.jst.go.jp/article/jts/45/2/45_109/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2021042665
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
• 抄録ライセンスフラグ: 使用不可