Selenoprotein P; P for Plasma, Prognosis, Prophylaxis, and More

• Tsutsumi Ryouhei

  Laboratory of Metabolism and Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University

• Saito Yoshiro

  Laboratory of Metabolism and Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University

抄録

Selenoprotein P (SeP) is one of the 25 human selenocysteine (Sec)-containing proteins, and is generally thought to function as a plasma carrier of the trace element selenium in the body. Recent studies, however, indicate unsuspected pivotal roles of SeP in human diseases, particularly in type 2 diabetes mellitus (T2DM) and pulmonary arterial hypertension (PAH). In this review, we will summarize the characteristics of SeP and recent advances in the field, especially focusing on the emerging roles of SeP in pathophysiological conditions. We will also discuss potential medical/pharmaceutical applications targeting SeP.

収録刊行物

• Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ

  Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 43 (3), 366-374, 2020-03-01

  公益社団法人 日本薬学会

キーワード

• selenoprotein P
• selenium
• type 2 diabetes mellitus
• pulmonary arterial hypertension

詳細情報

• CRID: 1390283659855544960
• NII論文ID: 130007804438
• NII書誌ID: AA10885497
• DOI: 10.1248/bpb.b19-00837
• ISSN: 13475215
• ISSN: 09186158
• NDL書誌ID: 030274628
• PubMed: 32115498
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I030274628
• Web Site: https://www.jstage.jst.go.jp/article/bpb/43/3/43_b19-00837/_pdf
• 本文言語コード: en
• データソース種別:
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  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
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