Selenoprotein P; P for Plasma, Prognosis, Prophylaxis, and More

• Tsutsumi Ryouhei

  Laboratory of Metabolism and Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University

• Saito Yoshiro

  Laboratory of Metabolism and Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University

Abstract

Selenoprotein P (SeP) is one of the 25 human selenocysteine (Sec)-containing proteins, and is generally thought to function as a plasma carrier of the trace element selenium in the body. Recent studies, however, indicate unsuspected pivotal roles of SeP in human diseases, particularly in type 2 diabetes mellitus (T2DM) and pulmonary arterial hypertension (PAH). In this review, we will summarize the characteristics of SeP and recent advances in the field, especially focusing on the emerging roles of SeP in pathophysiological conditions. We will also discuss potential medical/pharmaceutical applications targeting SeP.

Journal

• Biological and Pharmaceutical Bulletin

  Biological and Pharmaceutical Bulletin 43 (3), 366-374, 2020-03-01

  The Pharmaceutical Society of Japan

Keywords

• selenoprotein P
• selenium
• type 2 diabetes mellitus
• pulmonary arterial hypertension

Details

• CRID: 1390283659855544960
• NII Article ID: 130007804438
• NII Book ID: AA10885497
• DOI: 10.1248/bpb.b19-00837
• ISSN: 13475215
• ISSN: 09186158
• NDL BIB ID: 030274628
• PubMed: 32115498
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I030274628
• Web Site: https://www.jstage.jst.go.jp/article/bpb/43/3/43_b19-00837/_pdf
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed