Effects of exercise on biological trace element concentrations and selenoprotein P expression in rats with fructose-induced glucose intolerance

• Miya Namika

  Department of Analytical and Bioinorganic Chemistry, Division of Analytical and Physical Sciences, Kyoto Pharmaceutical University Department of Health Sports and Nutrition, Faculty of Health and Welfare, Kobe Women’s University

• Uratani Asuka

  Department of Health Sports and Nutrition, Faculty of Health and Welfare, Kobe Women’s University

• Chikamoto Keita

  CycloChem Bio Co., Ltd.

• Naito Yuki

  Department of Analytical and Bioinorganic Chemistry, Division of Analytical and Physical Sciences, Kyoto Pharmaceutical University

• Terao Keiji

  CycloChem Bio Co., Ltd.

• Yoshikawa Yutaka

  Department of Health Sports and Nutrition, Faculty of Health and Welfare, Kobe Women’s University

• Yasui Hiroyuki

  Department of Analytical and Bioinorganic Chemistry, Division of Analytical and Physical Sciences, Kyoto Pharmaceutical University

Abstract

In the present study, we investigated the effects of exercise intended to prevent or treat lifestyle-related diseases on the glucose tolerance, insulin level, lactic acid utilization, muscle glycogen synthesis, hepatic and renal oxidative stress, hepatic selenoprotein P and biological trace element levels in organs of obese, glucose-intolerant rats. We fed normal, healthy rats a 20% casein diet while the glucose-intolerant, obese rats received a high-fructose diet. They were forced to run for one hour per day, six days per week, for ten weeks. Exercise reduced visceral fat and ameliorated glucose tolerance in the high-fructose group, lowered blood lactic acid levels, improved lactic acid usage efficiency, and increased oxidative stress and hepatic levels of Mn, Fe, Cu, and Zn in the normal and high-fructose groups. Additionally, exercise significantly upregulated hepatic selenoprotein P expression in both groups, however, its effect was remarkable in healthy group. On the other hand, muscle glycogen synthesis was not markedly enhanced in high-fructose-diet rats but in normal-diet rats in response to exercise. It is concluded that exercise conditions rather than exercise load must be customized and optimized for each health and disease states in advance before starting exercise training intended to prevent or treat lifestyle-related diseases.

Journal

• Journal of Clinical Biochemistry and Nutrition

  Journal of Clinical Biochemistry and Nutrition 66 (2), 124-131, 2020-03-01

  SOCIETY FOR FREE RADICAL RESEARCH JAPAN

Keywords

• exercise effect
• glucose intolerance
• selenoprotein P
• biological trace elements

Details

• CRID: 1390846609808860160
• NII Article ID: 130007804504
• DOI: 10.3164/jcbn.19-96
• ISSN: 18805086
• ISSN: 09120009
• Web Site: https://www.jstage.jst.go.jp/article/jcbn/66/2/66_19-96/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2021000139
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed