Association of Basophil-Expressing Genes with Effectiveness of Sublingual Immunotherapy
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- Gotoh Minoru
- Department of Otorhinolaryngology, Nippon Medical School Allergy and Immunology Project, The Tokyo Metropolitan Institute of Medical Science
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- Kaminuma Osamu
- Allergy and Immunology Project, The Tokyo Metropolitan Institute of Medical Science Department of Disease Model, Research Institute of Radiation Biology and Medicine, Hiroshima University
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- Nakaya Akihiro
- Allergy and Immunology Project, The Tokyo Metropolitan Institute of Medical Science Department of Genome Informatics, Graduate School of Medicine, Osaka University
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- Saeki Mayumi
- Allergy and Immunology Project, The Tokyo Metropolitan Institute of Medical Science
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- Nishimura Tomoe
- Allergy and Immunology Project, The Tokyo Metropolitan Institute of Medical Science
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- Kitamura Noriko
- Allergy and Immunology Project, The Tokyo Metropolitan Institute of Medical Science
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- Hiroi Takachika
- Allergy and Immunology Project, The Tokyo Metropolitan Institute of Medical Science
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- Okubo Kimihiro
- Department of Otorhinolaryngology, Nippon Medical School Allergy and Immunology Project, The Tokyo Metropolitan Institute of Medical Science
Abstract
<p>Basophils were reported to be associated with allergy pathogenesis and the efficacy of allergen immunotherapy. Using a purified cedar allergen, we recently studied the effectiveness of sublingual immunotherapy for patients with Japanese cedar pollinosis. Patients were classified as high responders (HR) and nonresponders (NR), and comprehensive microarray analysis was used to examine peripheral basophils in both groups. A total of 153 genes were differentially expressed in HR and NR patients. Most of these differentially expressed genes encoded intracellular molecules, and expression levels were higher in HR patients than in NR patients. mRNA expression of the gene encoding D4, zinc, and double plant homeodomain (PHD) fingers family 2 (DPF2) was significantly correlated with copy number variation (CNV). Genetic variation in the DPF2 gene and its expression in basophils might be associated with the efficacy of sublingual immunotherapy.</p>
Journal
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- Journal of Nippon Medical School
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Journal of Nippon Medical School 87 (1), 49-52, 2020-02-15
The Medical Association of Nippon Medical School