Hb Phnom Penh Showing Falsely High or Reasonable HbA1c Values Depending on the Type of High-performance Liquid Chromatography System
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- Hara Kenji
- Department of Diabetes, Endocrinology and Hematology, Dokkyo Medical University Saitama Medical Center, Japan
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- Koga Masafumi
- Department of Internal Medicine, Hakuhokai Central Hospital, Japan
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- Shinozaki Hiroyuki
- Department of Diabetes, Endocrinology and Hematology, Dokkyo Medical University Saitama Medical Center, Japan
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- Yamauchi Mototaka
- Department of Diabetes, Endocrinology and Hematology, Dokkyo Medical University Saitama Medical Center, Japan
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- Suzuki Tatsuhiko
- Department of Diabetes, Endocrinology and Hematology, Dokkyo Medical University Saitama Medical Center, Japan
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- Naruse Rika
- Department of Diabetes, Endocrinology and Hematology, Dokkyo Medical University Saitama Medical Center, Japan
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- Tsuchiya Takafumi
- Department of Diabetes, Endocrinology and Hematology, Dokkyo Medical University Saitama Medical Center, Japan
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- Takebayashi Kohzo
- Department of Diabetes, Endocrinology and Hematology, Dokkyo Medical University Saitama Medical Center, Japan
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- Inukai Toshihiko
- Department of Diabetes, Endocrinology and Hematology, Dokkyo Medical University Saitama Medical Center, Japan
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- Hashimoto Koshi
- Department of Diabetes, Endocrinology and Hematology, Dokkyo Medical University Saitama Medical Center, Japan
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Abstract
<p>We herein report a 50-year-old Chinese woman with Hb Phnom Penh (α117Phe-Ile-α118Thr) showing high or reasonable HbA1c values depending on the type of high-performance liquid chromatography (HPLC) system. A high HbA1c value of 7.5% (HPLC assay: G9) and a reasonable HbA1c value of 5.2% (assay unknown) were observed. Therefore, the patient was refereed to our hospital; the oral glucose tolerance test showed normal glucose tolerance. The HbA1c values measured by an enzymatic assay, immunoassay, and affinity assay, as well as most HPLC assays were within the reference range, whereas those measured by the Tosoh HPLC systems were high. </p>
Journal
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- Internal Medicine
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Internal Medicine 59 (6), 805-809, 2020-03-15
The Japanese Society of Internal Medicine