Preparation and Properties of Dendritic sugar Immobilized Surface

• Fukuda Tomohiro

• Onogi Shunsuke

• Miura Yoshiko

抄録

Novel saccharide surfaces with well-defined multivalency were prepared using glycodendrimer. The glycodendrimer a-mannose (a-Man) was synthesized and immobilized onto the acetylenyl-terminated gold substrate via click chemistry. The saccharide-immobilized substrates were evaluated with FTIR-RAS and XPS. The biological abilities of the saccharide-immobilized substrate were evaluated by quarts crystal microbalance (QCM) with the lectins of concanavalin A (ConA), and wheat germ agglutinin. The lectin binding to the glycodendrimer array was quantitatively analyzed, and the association constant (KA) was revealed according to Scatchard plot. The kinetic constants were increase by glyco-dendrimer immobilization, and the multivalent effect of saccharide-lectin was exerted effectively.

収録刊行物

• Transactions of the Materials Research Society of Japan

  Transactions of the Materials Research Society of Japan 33 (3), 733-736, 2008

  一般社団法人 日本MRS

キーワード

• Glyco-dendrimer
• Self-Assembled Monolayer
• Multivalent Effect

詳細情報

• CRID: 1390002184882301312
• NII論文ID: 130007809580
• DOI: 10.14723/tmrsj.33.733
• ISSN: 21881650
• ISSN: 13823469
• Web Site: https://www.jstage.jst.go.jp/article/tmrsj/33/3/33_733/_pdf
• 本文言語コード: en
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• 抄録ライセンスフラグ: 使用不可