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- 船戸 弘正
- 東邦大・医・解剖 筑波大・IIIS
書誌事項
- タイトル別名
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- SIK family regulates sleep/wakefulness in mice
抄録
<p>Sleep is a behavior conserved from invertebrates to vertebrates, and tightly regulated in a homeostatic manner. The molecular and cellular mechanism determining the amount of sleep remains unknown. We established Sleepy mutant pedigrees through EEG/EMG-based screening of randomly mutagenized mice. The causative mutation for Sleepy mutant was a splicing mutation of Sik3 gene. The mutant SIK3 protein lacks a region containing a well-conserved protein kinase A-phosphorylated site, S551. We further investigated the molecular basis of sleep need using quantitative phosphoproteomic analysis of the sleep-deprived and Sik3 mutant mouse. The brain proteome of Sik3 mutant mice exhibits hyperphosphorylation, similar to that seen in that of sleep-deprived mice. The substitution of S551 into alanine residue resulted in a decreased time spent in wakefulness as original Sleepy mutant mice. I will present several on-going projects.</p>
収録刊行物
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- 日本薬理学会年会要旨集
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日本薬理学会年会要旨集 93 (0), 1-S12-1-, 2020
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390283659859525248
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- NII論文ID
- 130007811456
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- ISSN
- 24354953
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可