褐色脂肪組織熱産生における1型Na⁺/Ca²⁺交換輸送体の機能的関与

• 喜多 知

  福岡大・医

• 田頭 秀章

  福岡大・医

• 根本 隆行

  福岡大・医

• 喜多 紗斗美

  福岡大・医 徳島文理大・薬

• 岩本 隆宏

  福岡大・医

書誌事項

タイトル別名

• Functional involvement of Na⁺/Ca²⁺ exchanger type 1 in brown adipose tissue thermogenesis

抄録

Brown adipose tissue (BAT) is a primary site for non-shivering thermogenesis in mammals. In cold temperature, β-adrenergic stimulation activates mitochondrial uncoupling protein 1 (UCP1), which consequently generates heat by uncouples of the respiratory chain. Previous report suggested that intracellular Ca²⁺ signaling induced by transient receptor potential vanilloid 2 (TRPV2) activates UCP1 in BAT thermogenesis. However, molecular mechanisms of intracellular Ca²⁺ signaling in BAT are not well characterized. We have been systematically studying the physiological functions of Na⁺/Ca²⁺ exchangers, which regulate intracellular Ca²⁺ signaling. Recently, we found that Na⁺/Ca²⁺ exchanger type 1 (NCX1) is abundantly expressed in interscapular BAT (iBAT) from wild-type mice. Therefore, in this study, our research interest focuses on elucidating functional involvement of NCX1 in BAT thermogenesis. Intriguingly, we observed that NCX1-heterozygous (NCX^+/-) mice did not maintain their core body temperature in cold exposure. Furthermore, UCP1 transcripts in iBAT were significantly decreased in NCX^+/- mice compared with wild-type mice. These results suggest that NCX1 may contribute to BAT thermogenesis against cold environment.

収録刊行物

• 日本薬理学会年会要旨集

  日本薬理学会年会要旨集 93 (0), 3-O-087-, 2020

  公益社団法人 日本薬理学会

キーワード

• brown adipocyte
• transporter
• ion channel

詳細情報

• CRID: 1390283659859318784
• NII論文ID: 130007811794
• DOI: 10.1254/jpssuppl.93.0_3-o-087
• ISSN: 24354953
• Web Site: https://www.jstage.jst.go.jp/article/jpssuppl/93/0/93_3-O-087/_pdf
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可