書誌事項
- タイトル別名
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- Myocardial atrophy regulated by the formation of TRPC3 protein complex
抄録
<p>Myocardial atrophy, characterized by the decreases in size and contractility of cardiomyocytes, is caused by severe malnutrition and/or mechanical unloading. We have investigated the mechanism underlying induction of myocardial atrophy induced by anti-cancer drug treatment, and found that formation of protein complex between NADPH oxidase 2 (Nox2) and transient receptor potential canonical (TRPC) 3 contributed to ROS-mediated myocardial atrophy in mice. Here, we report that extracellular adenosine 5'-triphosphate (ATP) promotes nutrient deficiency-induced cardiomyocyte atrophy through TRPC3-Nox2 complex formation. Knockdown of either TRPC3 or Nox2 suppressed nutritional deficiency-induced ATP release, as well as ROS production and NRCM atrophy, suggesting that the formation of TRPC3-Nox2 protein complex amplifies ATP-induced myocardial atrophy. Taken together, we propose that TRPC3-Nox2 axis mediates nutritional deficiency-induced cardiomyocyte atrophy by promoting ATP release.</p>
収録刊行物
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- 日本薬理学会年会要旨集
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日本薬理学会年会要旨集 93 (0), 3-S31-1-, 2020
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390002184882899584
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- NII論文ID
- 130007811963
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- ISSN
- 24354953
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可