気管支喘息モデルマウスでのステロイド薬の抗炎症作用における骨髄由来免疫抑制細胞（MDSCs）の役割

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  • Myeloid-derived suppressor cells (MDSCs) are involved in anti-asthmatic effect of glucocorticoid in OVA-sensitized mice

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<p>Myeloid-derived suppressor cells (MDSCs) are heterogeneous population of immunosuppressive myeloid progenitor cells. We have previously shown that MDSCs are increased and play protective role in OVA-sensitized mice lung. On the other hand, glucocorticoid is the most commonly used anti-inflammatory drug for asthma. The aim of this study is, therefore, to define the potential role of MDSCs in anti-asthmatic effect of glucocorticoid. Dexamethasone (DEX) enhanced differentiation from bone marrow cells into MDSCs under co-stimulation of IL-6/GM-CSF in vitro, which was inhibited by mifepristone, a glucocorticoid receptor antagonist. DEX-treated MDSCs showed potent inhibitory effect of T cell proliferation. Consistent with in vitro results, administration of DEX significantly increased a population of MDSCs, accompanied by resolution of inflammation in lung of OVA-sensitized mice. By contrast, inhibition of MDSCs attenuated the effect of DEX. Taken together, these data reveal a novel role of MDSCs in anti-inflammatory effect of glucocorticoid and further implicated pharmacological targeting of MDSCs as a potential therapeutic strategy in asthma.</p>

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