Study on prognostic factor for oral cancer by inflammation based prognostic score

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  • Kubota Kosei
    Department of Dentistry and Oral Surgery, Hirosaki University Graduate School of Medicine
  • Ito Ryohei
    Department of Dentistry and Oral Surgery, Hirosaki University Graduate School of Medicine
  • Narita Norihiko
    Department of Dentistry and Oral Surgery, Hirosaki University Graduate School of Medicine
  • Nakagawa Hiroshi
    Department of Dentistry and Oral Surgery, Hirosaki University Graduate School of Medicine
  • Tanaka Yusuke
    Department of Dentistry and Oral Surgery, Hirosaki University Graduate School of Medicine
  • Fukuta Haruka
    Department of Dentistry and Oral Surgery, Hirosaki University Graduate School of Medicine
  • Kobayashi Wataru
    Department of Dentistry and Oral Surgery, Hirosaki University Graduate School of Medicine

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  • Inflammation based prognostic scoreを用いた口腔癌の予後因子の検討

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Abstract

Neutrophil-to-lymphocyte ratio （NLR）, platelet-to-lymphocyte ratio （PLR）, lymphocyte-to-monocyte ratio （LMR） and progressive nutrition index（PNI） are known as inflammation based prognostic scores（IBPS）, and have been reported as prognostic indicators for various cancers. We studied 101 patients who underwent curative surgery for oral squamous cell carcinoma in the Department of Dentistry and Oral Surgery, Hirosaki University Hospital between January 2008 and December 2016. IBPS was calculated from peripheral blood before surgery and at the time of recurrence or metastasis. The optimal cut-off point of IBPS was determined on the basis of a time-dependent receiver operating characteristics curve for disease-free survival. The optimal cut-off point of NLR was 2.649, LMR was 5.379, PLR was 154.317 and PNI was 50.703. The high NLR group had a significantly lower survival rate than the low NLR group. Univariate analysis using a COX proportional-hazards model showed that NLR and presence or absence of reconstruction were significantly associated with poor outcomes. Multivariate analysis showed that NLR remained as a risk factor for disease-free survival.<br>In the recurrence or metastasis group, a comparison of IBPS between pretreatment and the time of recurrence or metastasis was performed. In the case of recurrence or metastasis a significant reduction of PNI was observed. Thus, we suggest that pretreatment NLR was an important predictive factor for the prognosis of recurrence or metastasis, and PNI was the same during follow-up.

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