Probiotics/prebiotics cannot prevent the onset of allergy

• Ohshima Yusei

  Department of Pediatrics, Faculty of Medical Sciences, University of Fukui

Bibliographic Information

Other Title

• プロ・プレバイオティクスによるアレルギー予防は可能か
• Con：アレルギーの予防は不可能である

Abstract

Accumulating evidences on the immunological mechanisms of probiotics and prebiotics suggest their potential effects for prevention of allergic diseases. Meta-analysis and systematic reviews of interventional studies revealed that probiotics reduced the risk of eczema but not other allergic conditions, whereas prebiotics decreased the risk of developing food allergies and wheeze/asthma. The certainty in the evidences is very low due to the risk of publishing bias, inconsistency and imprecision of the results. Therefore, major guidelines don't actively recommend probiotics and prebiotics for prevention of allergic diseases. Because of the diminution of regulatory T cell inducing ability of probiotics and prebiotics after their discontinuation and the refractoriness of some high-risk infants, probiotics and prebiotics are not recommended without the establishment of measures to identify suitable subjects and the intervention procedures.

Journal

• Nihon Shoni Arerugi Gakkaishi. The Japanese Journal of Pediatric Allergy and Clinical Immunology

  Nihon Shoni Arerugi Gakkaishi. The Japanese Journal of Pediatric Allergy and Clinical Immunology 34 (1), 153-157, 2020-03-20

  THE JAPANESE SOCIETY OF PEDIATRIC ALLERGY AND CLINICAL IMMUNOLOGY

Keywords

• intestinal microbial flora
• prebiotics
• probiotics

Details

• CRID: 1390565134840145792
• NII Article ID: 130007815628
• DOI: 10.3388/jspaci.34.153
• ISSN: 18822738
• ISSN: 09142649
• Web Site: https://www.jstage.jst.go.jp/article/jspaci/34/1/34_153/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2020379324
• Text Lang: ja
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed