Tension-dependent Generation of Biochemical Signals on Actomyosin Fibers

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  • HIRATA Hiroaki
    Mechanobiology Laboratory, Nagoya University Graduate School of Medicine
  • SOKABE Masahiro
    Mechanobiology Laboratory, Nagoya University Graduate School of Medicine

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  • アクトミオシンファイバーは張力依存的なシグナルを生成するプラットフォームとして機能する
  • アクトミオシンファイバー ワ チョウリョク イソンテキ ナ シグナル オ セイセイ スル プラットフォーム ト シテ キノウ スル

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Abstract

<p>Actomyosin fibers in non-muscle cells generate contractile force to drive cell morphogenesis and migration. We find another role of these fibers as a platform for generating force-dependent biochemical signals. The MAP kinase ERK is activated on actomyosin fibers in response to tension developed in the fibers, which contributes to detecting anisotropy of cell deformation. The actin-binding, myosin-modulating protein calponin-3 is also phosphorylated on actomyosin fibers dependently on the fiber tension, which in turn increases myosin-based contractile force generation in the fibers. This positive feedback mechanism for tension development in actomyosin fibers enhances generation of force-dependent biochemical signals on the fibers.</p>

Journal

  • Seibutsu Butsuri

    Seibutsu Butsuri 60 (2), 089-093, 2020

    The Biophysical Society of Japan General Incorporated Association

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