Analysis of salivary factors related to the oral health status in children
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- Shimomura-Kuroki Junko
- Department of Pediatric Dentistry, The Nippon Dental University School of Life Dentistry at Niigata
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- Nashida Tomoko
- Department of Biochemistry, The Nippon Dental University School of Life Dentistry at Niigata
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- Miyagawa Yukio
- The Nippon Dental University Graduate School of Life Dentistry at Niigata
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- Morita Takao
- Department of Biochemistry, The Nippon Dental University School of Life Dentistry at Niigata
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- Hayashi-Sakai Sachiko
- Division of Oral and Maxillofacial Radiology, Department of Oral Health Science, Course for Oral Life Science, Niigata University Graduate School of Medical and Dental Sciences
抄録
<p>Early detection of oral disease is important to reduce its severity and increase the likelihood of successful treatment. This study aimed to perform a quantitative assessment of the saliva components as a first stage of the research to screen oral homeostasis. Here, saliva secretions collected from children were evaluated, and their constituents were analyzed to investigate the potential correlations between the buffering capacity and a range of salivary factors. Subjects aged 3-16 years in the primary, mixed, or permanent dentition stage, were selected for this study. The following salivary factors were analyzed: flow rate, total protein, total sugar quantifications, and constituent analyses using RT-PCR and western blotting. The associations between each factor and the buffering capacity were then analyzed using multiple regression analysis. Flow rate, BPIFA2 RNA level, histatin 1 and BPIFB1 protein levels as well as female sex were positively associated with buffering capacity. In contrast, total sugar concentration and MUC7 RNA levels showed a negative relationship with the buffering capacity. Some of these constituents may indicate oral homeostasis and are therefore potential biomarkers of oral health status. These results suggest that the analyses of the correlations between oral homeostasis and salivary factors are an effective strategy for identifying the susceptibility to oral diseases.</p>
収録刊行物
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- Ｊｏｕｒｎａｌ ｏｆ Ｏｒａｌ Ｓｃｉｅｎｃｅ
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Ｊｏｕｒｎａｌ ｏｆ Ｏｒａｌ Ｓｃｉｅｎｃｅ 62 (2), 226-230, 2020
日本大学歯学部