Rat mandibular condyle and fossa grew separately then unified as a single joint at 20 days old, which was the weaning age
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- Satoh Keitaro
- Department of Regulatory Physiology, Dokkyo Medical University School of Medicine Department of Pharmacology, Asahi University School of Dentistry
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- Satoh Kaori
- Department of Regulatory Physiology, Dokkyo Medical University School of Medicine
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- Imaizumi-Ohashi Yoshie
- Department of Regulatory Physiology, Dokkyo Medical University School of Medicine
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- Yokoi-Hayakawa Mika
- Department of Regulatory Physiology, Dokkyo Medical University School of Medicine
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- Fukada Toshiyuki
- Faculty of Pharmaceutical Sciences, Tokushima Bunri University Division of Pathology, Department of Oral Diagnostic Sciences, School of Dentistry, Showa University Laboratory for Integrative Genomics, RIKEN Center for Integrative Medical Sciences
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- Seo Yoshiteru
- Department of Regulatory Physiology, Dokkyo Medical University School of Medicine
抄録
<p>Magnetic resonance imaging (MRI) was used to observe growth of the mandibular condyle, mandibular fossa, and articular disc as a single unit. Changes in each component’s relative position and size were observed using 7-tesla MRI. Mandibular condyle chondrocytes’ growth was evaluated with immunohistochemistry, using the expression of zinc transporter ZIP13. Three-dimensional T1-weighted (T1w) MRI was used to obtain images of the TMJ of Sprague Dawley rats at 4-78 days old (P4-78) with a voxel resolution of 65 μm. Two-dimensional T1w MR images were acquired after a subcutaneous injection of the contrast reagent gadolinium diethylenetriamine pentaacetic acid (Gd-DTPA). The T1w MR images showed that the mandibular condyle was located posterior to the mandibular fossa until P20; however, it then moved to a location underneath the mandibular fossa. In the Gd-DTPA enhanced images, the articular disc was identified as a region with lower signal intensity from P20. The number of ZIP13-positive chondrocytes at P6 was larger than the number at P24. In conclusion, the mandibular condyle with cartilage and disc grows on the posterior side of the mandibular fossa until P20, which was the weaning age. Then, the condyle fit into the mandibular fossa and completed the functional unit.</p>
収録刊行物
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- Ｊｏｕｒｎａｌ ｏｆ Ｏｒａｌ Ｓｃｉｅｎｃｅ
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Ｊｏｕｒｎａｌ ｏｆ Ｏｒａｌ Ｓｃｉｅｎｃｅ 62 (2), 197-201, 2020
日本大学歯学部