Serum Gamma-Glutamyltransferase, Daily Alcohol Consumption, and the Risk of Chronic Kidney Disease: The Kansai Healthcare Study
-
- Shibata Mikiko
- Preventive Medicine and Environmental Health, Osaka City University Graduate School of Medicine
-
- Sato Kyoko Kogawa
- Preventive Medicine and Environmental Health, Osaka City University Graduate School of Medicine
-
- Uehara Shinichiro
- Preventive Medicine and Environmental Health, Osaka City University Graduate School of Medicine
-
- Koh Hideo
- Hematology, Osaka City University Graduate School of Medicine
-
- Oue Keiko
- Preventive Medicine and Environmental Health, Osaka City University Graduate School of Medicine Kansai Health Administration Center, Nippon Telegraph and Telephone West Corporation
-
- Kambe Hiroshi
- Kansai Health Administration Center, Nippon Telegraph and Telephone West Corporation
-
- Morimoto Michio
- Kansai Health Administration Center, Nippon Telegraph and Telephone West Corporation
-
- Hayashi Tomoshige
- Preventive Medicine and Environmental Health, Osaka City University Graduate School of Medicine
Search this article
Abstract
<p>Background: Serum gamma-glutamyltransferase has been recognized as the risk factor of cardiovascular and metabolic diseases. However, the association between serum gamma-glutamyltransferase and the risk of chronic kidney disease is not well known, and no prospective studies have examined separately the relationship of serum gamma-glutamyltransferase with the risk of proteinuria versus that of low estimated glomerular filtration rate (eGFR).</p><p>Methods: We prospectively followed 9,341 Japanese men who did not have low eGFR, proteinuria, or diabetes, and did not take antihypertensive medications at entry for the analysis of proteinuria, and we followed 9,299 men for the analysis of low eGFR. We defined “persistent proteinuria” as proteinuria detected two or more times consecutively and persistently as ≥1+ on urine dipstick at the annual check-up until the end of follow-up. Low eGFR was defined as eGFR <60 mL/min/1.73 m2.</p><p>Results: During the 11-year observation period, 151 men developed persistent proteinuria and 1,276 men developed low eGFR. In multivariate models, the highest quartile (≥71 IU/L) of serum gamma-glutamyltransferase was independently related to the development of persistent proteinuria (hazard ratio 3.39; 95% confidence interval, 1.92–5.97) compared with the lowest quartile (≤25 IU/L). In joint analysis of alcohol consumption and serum gamma-glutamyltransferase, non-drinkers in the highest tertile (≥58 IU/L) of serum gamma-glutamyltransferase had the highest risk of persistent proteinuria. However, there was no association between serum gamma-glutamyltransferase and low eGFR.</p><p>Conclusion: In middle-aged Japanese men, elevated serum gamma-glutamyltransferase was independently associated with future persistent proteinuria, but not with low eGFR.</p>
Journal
-
- Journal of Epidemiology
-
Journal of Epidemiology 30 (4), 163-169, 2020-04-05
Japan Epidemiological Association