Study Design and Baseline Profiles of Participants in the Uonuma CKD Cohort Study in Niigata, Japan
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- Kabasawa Keiko
- Department of Health Promotion Medicine, Niigata University Graduate School of Medical and Dental Sciences
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- Tanaka Junta
- Department of Health Promotion Medicine, Niigata University Graduate School of Medical and Dental Sciences
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- Nakamura Kazutoshi
- Division of Preventive Medicine, Niigata University Graduate School of Medical and Dental Sciences
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- Ito Yumi
- Department of Health Promotion Medicine, Niigata University Graduate School of Medical and Dental Sciences
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- Yoshida Kinya
- Department of Health Promotion Medicine, Niigata University Graduate School of Medical and Dental Sciences Division of Preventive Medicine, Niigata University Graduate School of Medical and Dental Sciences
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- Takachi Ribeka
- Department of Food Science and Nutrition, Nara Women’s University Graduate School of Humanities and Sciences
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- Sawada Norie
- Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center
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- Tsugane Shoichiro
- Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center
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- Narita Ichiei
- Department of Health Promotion Medicine, Niigata University Graduate School of Medical and Dental Sciences Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences
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Abstract
<p>Background: Evidence for primary prevention of chronic kidney disease (CKD) is insufficient. The population-based prospective Uonuma CKD cohort study aims to explore associations of lifestyle and other risk factors with CKD. We report here the study design and baseline profiles.</p><p>Methods: All 67,322 residents aged ≥40 years in Minamiuonuma City, Uonuma City, and Yuzawa Town, Niigata Prefecture, Japan and 11,406 participants who attended local health-check examinations were targeted for baseline questionnaire and biochemical sampling, respectively. Information was gathered from 43,217 (64.2%) questionnaires and 8,052 (70.6%) biochemical samples; 6,945 participants consented to both questionnaire and biochemical sampling at baseline, conducted between fiscal years 2012 and 2015. Participants provided information regarding sociodemographic, lifestyle, and self-reported outcomes. Urine albumin-to-creatinine ratio (ACR) and estimated glomerular filtration rate (eGFR) were measured. The primary outcome is CKD based on self-report and biochemical/clinical diagnosis.</p><p>Results: Mean age of questionnaire respondents was 63.3 (standard deviation [SD], 12.5) years for men and 64.3 (SD, 13.3) years for women. Among participants who submitted urine samples, median ACR was 10.0 (interquartile range [IQR], 5.0–24.0) mg/g for men and 13.0 (IQR, 7.7–27.0) mg/g for women, and median eGFR was 73.6 mL/min/1.73 m2 (IQR, 63.5–84.5) for men and 73.5 mL/min/1.73 m2 (IQR, 64.4–83.5) for women. ACR 30 mg/g or more was found in 1,741 participants (21.7%) and eGFR <60 mL/min/1.73 m2 in 1,361 participants (16.9%).</p><p>Conclusion: The Uonuma CKD cohort study was established to investigate the impact of lifestyle on CKD development and to provide data for preventing the onset and progression of CKD.</p>
Journal
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- Journal of Epidemiology
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Journal of Epidemiology 30 (4), 170-176, 2020-04-05
Japan Epidemiological Association
