Beta-hydroxy-beta-methylbutyrateの摂取と筋力運動の併用が閉経後女性の骨格筋量および筋力に及ぼす効果に関する予備的研究:ランダム化クロスオーバー試験  [in Japanese] Effects of beta-hydroxy-beta-methylbutyrate supplementation with resistance training on skeletal muscle mass and muscular strength in postmenopausal women: an open label randomized, controlled, cross-over, preliminary trial  [in Japanese]

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Abstract

<p><b>目的</b>:本研究の目的は,beta-hydroxy-beta-methylbutyrate(HMB)摂取と筋力運動の併用が閉経後女性の骨格筋量および筋力に及ぼす影響を検討することとした。研究デザインは,オープン化・クロスオーバー・ランダム化比較試験とし,研究期間は52週間(20週間のウォッシュアウト期間を含む)とした。</p><p><b>方法</b>:閉経後女性57名(60.2±6.0歳)をランダムに2 群(immediate intervention(II)群:29人,delayed intervention(DI)群:28人)に分けた。II群は最初の12週間にHMBと筋力運動による介入プログラムを提供した。その間,DI群は介入を行わず,最後の12週間にII群と同様の介入プログラムを提供した。なお,II群への介入終了後,20週間のウォッシュアウト期間を設けた。主要評価項目は四肢筋量,副次評価項目は最大筋力とした。</p><p><b>結果</b>:対照条件と比べて,介入条件の四肢筋量の変化値に有意な差はみられなかったが(介入条件 +0.2±0.8 kg,対照条件+0.3±0.8 kg,P = 0.88),最大筋力の変化値に有意な差がみられた(チェストプレス:介入条件+2.5±4.5 kg,対照条件0.0±5.0 kg,P < 0.001,レッグカール:介入条件+2.5±5.0 kg,対照条件0.0±5.0 kg,P = 0.001,レッグエクステンション:介入条件+12.5±7.5 kg,対照条件+5.0± 12.5 kg,P = 0.001)。</p><p><b>結論</b>:12週間にわたるHMBと筋力運動の併用は閉経後女性の筋力を向上させる可能性がある。</p>

<p><b>Objective:</b> A 52-week, open-label, randomized, controlled, cross-over with a wash-out period of 20 weeks, preliminary trial was performed to examine the effects of beta-hydroxy-beta-methylbutyrate (HMB) supplementation with resistance training on skeletal muscle mass and muscular strength in postmenopausal women.</p><p><b>Methods:</b> Fifty-seven postmenopausal women (mean age 60.2 ± 6.0 years) were randomly allocated to an immediate intervention group (IIG: n = 29) or delayed intervention group (DIG: n = 28). The IIG participated in our 12-week resistance training program along with HMB supplementation. No intervention was administered to the DIG during the initial 12-week period, and both groups were crossed over for the latter 12-week period. There was a 20-week wash-out between both periods. Effects of the intervention on primary (appendicular skeletal muscle mass: ASM) and secondary (maximum muscular strength: MMS) outcomes were examined for both baseline and post-intervention (12-week) periods.</p><p><b>Results:</b> Compared with control condition, intervention condition showed no significant improvement in ASM (intervention condition +0.2 ± 0.8 kg, control condition +0.3 ± 0.8 kg, <i>P</i> = 0.88), but showed significant improvement in MMS (chest press: intervention condition +2.5 ± 4.5 kg, control condition 0.0 ± 5.0 kg, <i>P</i> < 0.001, leg curl: intervention condition +2.5 ± 5.0 kg, control condition 0.0 ± 5.0 kg, <i>P</i> = 0.001, and leg extension: intervention condition +12.5 ± 7.5 kg, control condition +5.0 ± 12.5 kg, <i>P</i> = 0.001, respectively).</p><p><b>Conclusion:</b> These results suggest that HMB in combination with 12 weeks of resistance training for postmenopausal women caused greater improvement of muscle strength.</p>

Journal

  • Research in Exercise Epidemiology

    Research in Exercise Epidemiology 22(1), 22-34, 2020

    Japanese Association of Exercise Epidemiology

Codes

  • NII Article ID (NAID)
    130007830256
  • NII NACSIS-CAT ID (NCID)
    AA11865338
  • Text Lang
    JPN
  • ISSN
    1347-5827
  • NDL Article ID
    030377674
  • NDL Call No.
    Z74-C960
  • Data Source
    NDL  J-STAGE 
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