Hepatitis-associated Aplastic Anemia with Rapid Progression of Liver Fibrosis Due to Repeated Hepatitis

DOI HANDLE Web Site PubMed 11 References Open Access
  • Sawada Kenji
    Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Japan
  • Takai Atsushi
    Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Japan
  • Yamada Tomoyo
    Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Japan
  • Araki Osamu
    Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Japan
  • Yamauchi Yuki
    Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Japan
  • Eso Yuji
    Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Japan
  • Takahashi Ken
    Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Japan
  • Shindo Takero
    Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Japan
  • Sakurai Takaki
    Department of Diagnostic Pathology, Graduate School of Medicine, Kyoto University, Japan
  • Ueda Yoshihide
    Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Japan
  • Seno Hiroshi
    Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Japan

Abstract

<p>Hepatitis-associated aplastic anemia (HAAA) is a variant of acquired aplastic anemia and characterized by bone marrow failure that follows the development of acute hepatitis. We herein report a rare case of HAAA with rapid progression of liver fibrosis due to repeated hepatitis. A pathological examination of liver specimens revealed liver fibrosis progression over a short period. Immunosuppressive therapy with cyclosporine effectively cured both the pancytopenia and hepatitis. Our case suggests that the pathological examination of the liver tissue is useful for determining a treatment plan and that immunosuppressive therapy is a promising treatment for both aplastic anemia and persistent hepatitis. </p>

Journal

  • Internal Medicine

    Internal Medicine 59 (8), 1035-1040, 2020-04-15

    The Japanese Society of Internal Medicine

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