Sectional Imaging of <i>in vivo</i> Rat Brain Using Short Multimode Fiber Probe

• Sato Manabu

  Graduate Program of Electrical Engineering, Graduate School of Science and Engineering, Yamagata University

• Eto Kai

  Graduate Program of Electrical Engineering, Graduate School of Science and Engineering, Yamagata University

• Masuta Junpei

  Graduate Program of Electrical Engineering, Graduate School of Science and Engineering, Yamagata University

• Inoue Kenji

  Graduate Program of Electrical Engineering, Graduate School of Science and Engineering, Yamagata University

• Kurotani Reiko

  Graduate Program of Electrical Engineering, Graduate School of Science and Engineering, Yamagata University

• Abe Hiroyuki

  Graduate Program of Electrical Engineering, Graduate School of Science and Engineering, Yamagata University

• Nishidate Izumi

  Graduate School of Bio-Applications and Systems Engineering, Tokyo University of Agriculture and Technology

Bibliographic Information

Other Title

• ショートマルチモードファイバープローブを用いた<i>in vivo</i>ラット脳の断層イメージング

Abstract

We demonstrate full-field optical coherence microscopy (FF-OCM) using an ultrathin forward-imaging short multimode fiber (SMMF) probe with a core diameter of 50 μm, outer diameter of 125 μm, and length of 7.4 mm, which is a typical graded-index multimode fiber used for optical communications. The axial and lateral resolutions were measured to be 2.14 μm and 2.3 μm, respectively. Inserting the SMMF 4 mm into the cortex of an in vivo rat brain, depths were scanned from a SMMF facet to 147 μm with a field of view of 47 μm. Three-dimensional (3D) OCM images were obtained at depths from about 20 μm to 90 μm. From morphological information of the resliced 3D images and the dependence of the integration of the OCM image signal on the inserted distance, the 3D information of nerve fibers have been demonstrated.

Journal

• Nippon Laser Igakkaishi

  Nippon Laser Igakkaishi 41 (1), 9-17, 2020-04-15

  Japan Society for Laser Surgery and Medicine

Keywords

• optical coherence microscopy
• imaging probe
• multimode fiber
• nerve fiber

Details

• CRID: 1390285300151089024
• NII Article ID: 130007832471
• DOI: 10.2530/jslsm.jslsm-40_0053
• ISSN: 18811639
• ISSN: 02886200
• Web Site: https://www.jstage.jst.go.jp/article/jslsm/41/1/41_jslsm-40_0053/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2020324156
• Text Lang: ja
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed