Higher modified Glasgow Prognostic Score and multiple stapler firings for rectal transection are risk factors for anastomotic leakage after low anterior resection in rectal cancer
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- Sakamoto Wataru
- Department of Gastrointestinal Tract Surgery, Fukushima Medical University
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- Ohki Shinji
- Department of Gastrointestinal Tract Surgery, Fukushima Medical University
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- Kikuchi Tomohiro
- Department of Gastrointestinal Tract Surgery, Fukushima Medical University
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- Okayama Hirokazu
- Department of Gastrointestinal Tract Surgery, Fukushima Medical University
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- Fujita Shotaro
- Department of Gastrointestinal Tract Surgery, Fukushima Medical University
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- Endo Hisahito
- Department of Gastrointestinal Tract Surgery, Fukushima Medical University
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- Saito Motonobu
- Department of Gastrointestinal Tract Surgery, Fukushima Medical University
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- Saze Zenichiro
- Department of Gastrointestinal Tract Surgery, Fukushima Medical University
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- Momma Tomoyuki
- Department of Gastrointestinal Tract Surgery, Fukushima Medical University
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- Kono Koji
- Department of Gastrointestinal Tract Surgery, Fukushima Medical University
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Abstract
<p>Objective: Anastomotic leakage (AL) is one of the most devastating complications of rectal cancer surgery. Not only does AL result in reduced quality of life, extended hospitalization and impaired defecatory function, it also has a high local recurrence rate. In this study, we investigated risk factors for AL as it may help to decrease its occurrence and improve patient outcomes. </p><p>Methods: This study was a retrospective, single-institution study of rectal cancer patients who underwent elective low anterior resection between April 2002 and February 2018 at Fukushima Medical University Hospital. Patients were divided into two groups according to the presence of AL. Patient-, tumor-, and surgery-related variables were examined using univariate and multivariate analyses. </p><p>Results: One hundred sixty-one patients, average age 63.5±11.5 years, were enrolled in the study. The overall AL rate was 6.8% (11/161). In the univariate analysis, modified Glasgow Prognostic Score (mGPS)=2 (p=0.003), use of multiple staplers (≥3 firings) for rectal transection (p=0.001) and intraoperative bleeding (≥250 g) were significantly associated with AL incidence. Multivariate analysis identified that mGPS = 2 (odds ratio [OR]: 19.6, 95% confidence interval [CI]: 2.96-125.00, p=0.002) and multiple firings (OR: 18.19, CI: 2.31-111.11, p=0.002) were independent risk factors for AL.</p><p>Conclusion: Higher mGPS score and multiple firings were independent risk factors for AL. </p>
Journal
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- FUKUSHIMA JOURNAL OF MEDICAL SCIENCE
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FUKUSHIMA JOURNAL OF MEDICAL SCIENCE 66 (1), 10-16, 2020
THE FUKUSHIMA SOCIETY OF MEDICAL SCIENCE
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Keywords
Details 詳細情報について
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- CRID
- 1390566775129078656
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- NII Article ID
- 130007834284
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- NII Book ID
- AA0065246X
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- ISSN
- 21854610
- 00162590
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- PubMed
- 32074522
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- Text Lang
- en
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- Data Source
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- JaLC
- IRDB
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed