Successful prediction of clinical outcomes using arterial velocity pulse index, a new non-invasive vascular index, in Japan

Sasaki-Nakashima Rie, Ishigami Tomoaki, Kino Tabito, Teranaka-Saigo Sae, Chen Lin, Doi Hiroshi, Sugiyama Michiko, Minegishi Shintaro, Arakawa Kentaro, Abe Kaito, Wakui Hiromichi, Azushima Kengo, Tamura Kouichi, Kimura Kazuo

doi:10.30548/vascfail.3.2_43

<p>Objectives: Earlier detection of vascular stiffness and endothelial dysfunction will be useful in preventing atherosclerotic catastrophic conditions. Individuals with high risks for future cardiovascular (CV) events should be recognized by physicians to strengthen preventive therapeutic procedures, such as antihypertensive therapy, antidiabetic therapy, and antidyslipidemic therapy. As such, various non-invasive devices have been developed and are currently applied in clinical settings. Among them, we previously reported arterial velocity pulse index (AVI) and arterial pressure volume index (API) measured using a cuff-oscillometric-based medical electronic blood pressure monitor. These are significantly correlated with arterial stiffness and cardiac overload; therefore, these indexes might be useful in predicting future CV events. Materials and methods: We performed survival and CV event analyses in a total of 180 subjects with various clinical implications who visited Yokohama City University Hospital between May 2013 and March 2015 and followed them up until March 2016. The mean age was 66±13 years, and 101 subjects (56.1%) were men. A total of 116 subjects (64.4%) had hypertension, 87 subjects (48.3%) had dyslipidemia, and 39 subjects (21.7%) had diabetes mellitus. The mean AVI and API were 23.3±7.7 and 31.8±8.4, respectively. Results: The mean follow-up duration was 769±275 days. A total of 13 major adverse cardiac events (MACEs) occurred during the observational period, which consisted of 1 cardiac death, 8 CV events, and 4 hospitalizations owing to heart failure. After we performed Kaplan-Meier analysis, univariate Cox proportional hazard regression analysis, and multivariate Cox proportional hazard regression analysis, we found that AVI is significantly correlated with the risk of MACE. Therefore, we successfully revealed the clinical implications of the new non-invasive indexes for CV mortality and morbidity. Conclusion: The new non-invasive vascular index, AVI, was significantly correlated with the CV outcomes in our Japanese cohort.</p>

Successful prediction of clinical outcomes using arterial velocity pulse index, a new non-invasive vascular index, in Japan

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Successful prediction of clinical outcomes using arterial velocity pulse index, a new non-invasive vascular index, in Japan

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