Biofilm Formation by <i>Streptococcus mutans</i> is Enhanced by Indole via the Quorum Sensing Pathway

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Author(s)

Abstract

<p>Interspecies interactions among oral microorganisms in the pathogenic biofilms causing dental caries have not yet been elucidated in detail. We herein demonstrated that indole and its derivatives induced biofilm formation by <i>Streptococcus mutans</i>. Indole is an intercellular signaling molecule that is produced by oral bacteria other than <i>S. mutans</i>. The amounts of biofilm and extracellular DNA were significantly increased by the addition of indole and 4-hydroxyindole (4-HI). An examination with quorum sensing mutants showed that the induction of biofilm formation by indole and 4-HI required a quorum sensing system. These results suggest that this intercellular signaling molecule plays a role in pathogenic biofilm formation.</p>

Journal

  • Microbes and Environments

    Microbes and Environments 35(2), n/a, 2020

    Japanese Society of Microbial Ecology / Japanese Society of Soil Microbiology / Taiwan Society of Microbial Ecology / Japanese Society of Plant Microbe Interactions / Japanese Society for Extremophiles

Codes

  • NII Article ID (NAID)
    130007837477
  • NII NACSIS-CAT ID (NCID)
    AA11551577
  • Text Lang
    ENG
  • ISSN
    1342-6311
  • NDL Article ID
    030475417
  • NDL Call No.
    Z54-J644
  • Data Source
    NDL  J-STAGE 
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