Sex-Specific Association between Serum Vitamin D Status and Lipid Profiles: A Cross-Sectional Study of a Middle-Aged and Elderly Chinese Population

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  • HUANG Fei
    Department of Nephrology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
  • LIU Qingquan
    Department of Nephrology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
  • ZHANG Qian
    Department of Nephrology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
  • WAN Zhengce
    Department of Health Management Centre, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
  • HU Liu
    Department of Health Management Centre, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
  • XU Ranran
    Department of Nephrology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
  • CHENG Anying
    Department of Nephrology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
  • LV Yongman
    Department of Nephrology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Department of Health Management Centre, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
  • WANG Le
    Department of Nephrology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology

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Abstract

<p>Studies have shown that vitamin D status might be associated with dyslipidaemia, but results are conflicting and there might exist sex differences. The aim of our study was to explore the sex-specific association between vitamin D status and serum lipids and atherogenic index of plasma (AIP, a predictor for atherosclerosis) among Chinese middle-aged and elderly adults. A total of 4,021 middle-aged and elderly participants from a health management centre were included in this cross-sectional study. The individuals were classified into tertiles according to serum 25(OH)D. Linear and logistic regression models were used to estimate the association between vitamin D levels and serum lipids among the tertiles. The mean serum 25(OH)D level was 21.60 (16.60-27.20) ng/mL in all participants. After adjusting for potential confounders, a 10 ng/mL increase in 25(OH)D was associated with decreases of 1.156 mmol/L in triglycerides (TGs) and 0.068 in the AIP and an increase of 0.051 mmol/L in high-density lipoprotein cholesterol (HDL-C) in all subjects. In addition, 25(OH)D deficiency was associated with an increased prevalence of hypertriglyceridaemia (odds ratio (OR), 1.880; 95% confidence interval (CI), 1.351-2.615), hypoalphalipoproteinaemia/HDL (OR, 1.505; 95% CI, 1.146-1.977) and abnormal AIP (OR, 1.933; 95% CI, 1.474-2.534) in males, and 25(OH)D-deficient women had a 2.02-fold higher risk for hypoalphalipoproteinaemia/HDL than women with sufficient 25(OH)D levels (95% CI, 1.044-3.904; all p values <0.05). Vitamin D deficiency was positively associated with the prevalence of dyslipidaemia and abnormal AIP in the middle-aged and elderly Chinese population. And this association was stronger in men than in women.</p>

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