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- Sakamoto Miki
- Department of Physical therapy, Faculty of Rehabilitation, School of Allied Health Sciences, Kitasato University
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- Maehara Azusa
- Department of Physical therapy, Faculty of Rehabilitation, School of Allied Health Sciences, Kitasato University
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- Muro Masuo
- Exercise Physiology Laboratory, Toho University School of Medicine
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- Oka Kazuyuki
- Department of Biology, Toho University School of Medicine
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<p> Introduction: It is known that skeletal muscle with disuse atrophy exhibits reduction of muscle mass, diminution of fiber cross-sectional area (FCSA), etc. In the process of disuse atrophy, it is also known that the number of leukocytes and the frequency of cell division of non-endothelial cells are increased in the interstitium. We investigated the condition of disuse atrophy and the numerical changes of interstitial free mononuclear cells with the passage of time after immobilization.</p><p> Materials and methods: The soleus muscles of ICR mice were used in this study. In the immobilized groups, the left hindlimb was immobilized at the ankle joint at maximum planter flexion. After routine ATPase staining, FCSA of each muscle fiber (type I, type II) was measured separately. The number of interstitial free mononuclear cells per unit area (500 × 500 µm) was counted by using longitudinal paraffin sections stained by hematoxylin-eosin and it was defined as the interstitial free mononuclear cell index.</p><p> Results: FCSA of both type I and type II fibers were smaller in each immobilized group compared to the control group. The interstitial free mononuclear cell index tended to show a rapid increase after 3 days of immobilization and the index tended to be continuously higher compared with the control group after day 3.</p><p> Discussion: By comparing FCSA and the interstitial free mononuclear cell index, it was speculated that the state of muscle disuse atrophy can be evaluated easily and promptly using the interstitial free mononuclear cell index.</p>
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- 日本健康行動科学会学術雑誌
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日本健康行動科学会学術雑誌 10 (2), 93-100, 2012
日本健康行動科学会
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詳細情報 詳細情報について
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- CRID
- 1390003825180173312
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- NII論文ID
- 130007841712
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- NII書誌ID
- AA11988961
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- ISSN
- 24347132
- 13480898
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- NDL書誌ID
- 023661804
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可