Development of Surface Modification Methods Based on Specific Affinities of Polymer–binding Peptides

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  • Sawada Toshiki
    Department of Chemical Science and Engineering, School of Materials and Chemical Technology, Tokyo Institute of Technology
  • Serizawa Takeshi
    Department of Chemical Science and Engineering, School of Materials and Chemical Technology, Tokyo Institute of Technology

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Other Title
  • 合成高分子の構造を識別するペプチドを利用した修飾基盤技術の開発
  • ゴウセイ コウブンシ ノ コウゾウ オ シキベツ スル ペプチド オ リヨウ シタ シュウショク キバン ギジュツ ノ カイハツ

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Abstract

Biomolecules show excellent properties required for molecular recognition. These smart characteristics have been obtained through evolutional processes, and these biomolecules have been utilized in natural systems. Recently, their excellent capabilities have been used in materials science and engineering as well as life science. The bioinspired peptide screening technology using phage display methods has been developed based on the evolution to generate functional peptides. Here, we focused on peptides with a specific affinity for synthetic polymers. The polymer– binding peptides were obtained from a biologically constructed phage–displayed peptide library to recognize polymeric nanostructures, and were utilized for possible applications as novel biomolecular tools for functional polymers. Our approach to utilize peptides in materials science and engineering will open excellent opportunities for the next–generation of materials science and engineering.

Journal

  • MEMBRANE

    MEMBRANE 45 (3), 100-107, 2020

    THE MEMBRANE SOCIETY OF JAPAN

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