Impact of Diabetes Mellitus on the Aortic Wall Changes as Atherosclerosis Progresses: Aortic Dilatation and Calcification
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- Iwakawa Naoki
- Department of Cardiology, Nagoya University Graduate School of Medicine
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- Tanaka Akihito
- Department of Cardiology, Nagoya University Graduate School of Medicine
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- Ishii Hideki
- Department of Cardiology, Nagoya University Graduate School of Medicine
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- Kataoka Takashi
- Department of Cardiology, Nagoya University Graduate School of Medicine
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- Niwa Kiyoshi
- Department of Cardiology, Nagoya University Graduate School of Medicine
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- Hitora Yusuke
- Department of Cardiology, Nagoya University Graduate School of Medicine
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- Tashiro Hiroshi
- Department of Cardiology, Nagoya University Graduate School of Medicine
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- Mitsuda Takayuki
- Department of Cardiology, Nagoya University Graduate School of Medicine
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- Kojima Hiroki
- Department of Cardiology, Nagoya University Graduate School of Medicine
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- Hirayama Kenshi
- Department of Cardiology, Nagoya University Graduate School of Medicine
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- Furusawa Kenji
- Department of Cardiology, Nagoya University Graduate School of Medicine
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- Yoshida Ruka
- Department of Cardiology, Nagoya University Graduate School of Medicine
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- Suzuki Susumu
- Department of Cardiology, Nagoya University Graduate School of Medicine
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- Murohara Toyoaki
- Department of Cardiology, Nagoya University Graduate School of Medicine
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<p>Aim: An inverse association between diabetes mellitus (DM) and aortic dilatation has recently been reported. However, little is known about the association between DM and the progression of aortic dilatation/calcification as atherosclerosis progresses. </p><p>Methods: We identified 216 patients who had undergone percutaneous coronary intervention (PCI) and abdominal computed tomography (CT) during the PCI and follow-up phases. The patients were classified into two groups: those with DM (DM+ group; n=107) and those without DM (DM− group; n=109). The infrarenal aortic diameter and aortic calcification index (ACI) were measured, and annual changes were calculated using measurement results obtained during the PCI and follow-up phases. </p><p>Results: Infrarenal aortic diameters were significantly shorter in the DM+ group than in the DM- group during the PCI phase, and no significant ACI differences were observed between the DM+ and DM− groups. The median duration between the PCI and follow-up phase CT was 3.0 years. The growth rate of the infrarenal aortic dilatation from the PCI phase in the DM+ group was similar to that in the DM− group. Annual ACI changes were significantly larger in the DM+ group than in the DM− group. Multivariate logistic regression analysis indicated that the prevalence of DM was an independent predictor of rapid aortic calcification progression (odds ratio: 2.51; 95% confidence interval: 1.23-5.14; p=0.01). </p><p>Conclusion: Our findings suggest that DM negatively affects aortic dilatation during an earlier phase of atherosclerosis progression and positively affects the progression of aortic calcification in a later phase.</p>
収録刊行物
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- Ｊｏｕｒｎａｌ ｏｆ Ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ ａｎｄ Ｔｈｒｏｍｂｏｓｉｓ
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Ｊｏｕｒｎａｌ ｏｆ Ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ ａｎｄ Ｔｈｒｏｍｂｏｓｉｓ 27 (6), 509-515, 2020-06-01
一般社団法人 日本動脈硬化学会
