Prediction of Medium-Term Mortality in Japanese Patients With Wild-Type Transthyretin Amyloidosis

• Ochi Yuri

  Department of Cardiology and Geriatrics, Kochi Medical School, Kochi University

• Kubo Toru

  Department of Cardiology and Geriatrics, Kochi Medical School, Kochi University

• Baba Yuichi

  Department of Cardiology and Geriatrics, Kochi Medical School, Kochi University

• Nakashima Yasuteru

  Department of Cardiology and Geriatrics, Kochi Medical School, Kochi University

• Ueda Motoko

  Department of Cardiology and Geriatrics, Kochi Medical School, Kochi University

• Takahashi Asa

  Department of Cardiology and Geriatrics, Kochi Medical School, Kochi University

• Miyagawa Kazuya

  Department of Cardiology and Geriatrics, Kochi Medical School, Kochi University

• Noguchi Tatsuya

  Department of Cardiology and Geriatrics, Kochi Medical School, Kochi University

• Hirota Takayoshi

  Department of Cardiology and Geriatrics, Kochi Medical School, Kochi University

• Yamasaki Naohito

  Department of Cardiology and Geriatrics, Kochi Medical School, Kochi University

• Kitaoka Hiroaki

  Department of Cardiology and Geriatrics, Kochi Medical School, Kochi University

Abstract

Background:The prognostic factors in Japanese patients with wild-type transthyretin amyloidosis (ATTRwt) have not been elucidated. Methods and Results:In this study we retrospectively analyzed the clinical characteristics and outcomes of 47 patients with ATTRwt (mean (±SD) age at diagnosis 80.3±4.6 years; 41 males). Fifteen patients died within 2 years of their diagnosis. Receiver operating characteristic and Kaplan-Meier analyses revealed that the best predictors of 2-year mortality were low serum albumin (≤3.75 g/dL), elevated high-sensitivity cardiac troponin T (hs-cTnT; >0.086 ng/mL), and reduced left ventricular ejection fraction (LVEF; <50%). According to the total number of these 3 risk factors, patients were stratified into 4 subgroups: low risk (no risk factors; n=15), intermediate-low risk (1 risk factor; n=15), intermediate-high risk (2 risk factors; n=7), and high risk (3 risk factors; n=10). The estimated 2-year survival rate of patients classified as low risk, intermediate-low risk, intermediate-high risk, and high risk was 93%, 80%, 83%, and 11%, respectively (P<0.001). Conclusions:Low serum albumin, elevated hs-cTnT, and reduced LVEF are associated with a worse prognosis in Japanese patients with ATTRwt. The combination of these factors may be useful for predicting medium-term mortality in patients with ATTRwt.

Journal

• Circulation Reports

  Circulation Reports 2 (6), 314-321, 2020-06-10

  The Japanese Circulation Society

Keywords

• Albumin
• High-sensitivity cardiac troponin T
• Prognosis
• Wild-type transthyretin amyloidosis

Details

• CRID: 1390285300163154048
• NII Article ID: 130007853645
• DOI: 10.1253/circrep.cr-20-0031
• ISSN: 24340790
• Web Site: https://www.jstage.jst.go.jp/article/circrep/2/6/2_CR-20-0031/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2021043056
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed