Biomimetic Culture of Primary Neurons on an Ultrasoft Gel Surface

• SUMI Takuma

  Research Institute of Electrical Communication, Tohoku University

• YAMAMOTO Hideaki

  Research Institute of Electrical Communication, Tohoku University

• HIRANO-IWATA Ayumi

  Research Institute of Electrical Communication, Tohoku University Advanced Institute for Materials Research, Tohoku University

Bibliographic Information

Other Title

• 超軟ゲル表面を用いた神経細胞の生体模倣培養技術の開発
• チョウナンゲル ヒョウメン オ モチイタ シンケイ サイボウ ノ セイタイ モホウ バイヨウ ギジュツ ノ カイハツ

Abstract

Mechanical properties of scaffolds have recently been found to impose strong impact on the behavior of cultured cells. Here, we focused on the effect of scaffold's elastic modulus on the development of synaptic connections in cultured neurons, and developed a novel system for culturing rat cortical neurons on an ultrasolft gel surface with an elastic modulus resembling the brain.

Journal

• Vacuum and Surface Science

  Vacuum and Surface Science 63 (6), 298-303, 2020-06-10

  The Japan Society of Vacuum and Surface Science

Keywords

• soft material
• biointerface
• PDMS
• cell culture
• neuronal network

Details

• CRID: 1390003825186449280
• NII Article ID: 130007853653
• NII Book ID: AA12808657
• DOI: 10.1380/vss.63.298
• ISSN: 24335843
• ISSN: 24335835
• NDL BIB ID: 030486909
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I030486909
• Web Site: https://www.jstage.jst.go.jp/article/vss/63/6/63_20180566/_pdf
• Text Lang: ja
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed