The Comparison of the Efficacy of Baloxavir and Neuraminidase Inhibitors for Patients with Influenza A in Clinical Practice
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- Yoshii Naoko
- Department of Infection Control Science, Graduate School of Medicine, Osaka City University, Japan Department of Respiratory Medicine, Graduate School of Medicine, Osaka City University, Japan
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- Tochino Yoshihiro
- Department of Medical Education and General Practice, Graduate School of Medicine, Osaka City University, Japan
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- Fujioka Masashi
- Fujioka Pediatric Clinic, Japan
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- Sakazaki Hiromi
- Sakazaki Child Clinic, Japan
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- Maruyama Naomi
- Department of Respiratory Medicine, Graduate School of Medicine, Osaka City University, Japan
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- Asai Kazuhisa
- Department of Respiratory Medicine, Graduate School of Medicine, Osaka City University, Japan
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- Kakeya Hiroshi
- Department of Infection Control Science, Graduate School of Medicine, Osaka City University, Japan
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- Shintaku Haruo
- Department of Pediatrics, Graduate School of Medicine, Osaka City University, Japan
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- Kawaguchi Tomoya
- Department of Respiratory Medicine, Graduate School of Medicine, Osaka City University, Japan
抄録
<p>Objective Baloxavir marboxil is a novel anti-influenza drug reported to have an early antiviral effect, although it also causes the appearance of variant viruses with a reduced susceptibility to baloxavir. In Japan, four neuraminidase inhibitors (NAIs) have been commonly used to treat patients with influenza. In clinical practice, the differences in the effects of baloxavir and NAIs have not been sufficiently examined. Our objective was to clarify the clinical differences in efficacy between baloxavir and NAIs. </p><p>Methods A multicenter, observational study was conducted using postcard questionnaires during the 2018-19 influenza season. Patients who were prescribed anti-influenza drugs were provided postcard questionnaires asking about their background characteristics and their body temperatures. The factors associated with the early alleviation of the fever were analyzed, and the duration of the fever was compared between the baloxavir group and the NAI group. </p><p>Results A total of 295 patients with influenza A, ranging in age from 0-91 years old, were enrolled in this study. A multivariate analysis showed that treatment with baloxavir and a duration from the onset to the start of treatment ≥2.5 days were factors contributing to the early alleviation of the fever from the start of treatment. The duration of the fever was significantly shorter in the baloxavir group than in the NAI group (p=0.002). </p><p>Conclusion The present survey showed that baloxavir was significantly more effective than NAIs for treating patients with influenza A in clinical practice. </p>
収録刊行物
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- Internal Medicine
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Internal Medicine 59 (12), 1509-1513, 2020-06-15
一般社団法人 日本内科学会
