Is intermittent therapy of leukotriene receptor antagonist useful for episodic viral wheeze in children?

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  • Kawamoto Norio
    Department of Pediatrics, Graduate School of Medicine, Gifu University
  • Maeda Mayu
    Department of Pediatrics, Showa University School of Medicine
  • Takahashi Kyohei
    Department of Pediatrics, National Hospital Organization National Sagamihara Hospital
  • Adachi Yuichi
    Department of Pediatrics, Faculity of Medicine, University of Toyama

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  • CQ12　小児のウイルス感染による喘鳴の治療にロイコトリエン受容体拮抗薬は有用か？

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Abstract

<p>A systematic review (SR) was conducted to determine whether intermittent therapy of leukotriene receptor antagonist (LTRA) is useful for episodic viral wheeze in children. Randomized controlled trials (RCTs) were selected to compare the intervention of LTRA and control for the treatment of episodic viral wheeze in children. RCTs in children were selected from a previously published SR of children. Databases (CENTRAL, MEDLINE, and Embase) were searched for RCTs, which were written in English, and were published until December 2017. RCTs reported in Japanese were searched from a database of the Japan Medical Abstracts Society. Four RCTs were selected from a previously published SR, while none of RCT written in English and Japanese were selected from an additional search. These studies included patients with recurrent wheezing or asthma and were investigated the treatment for asthma attacks or wheezing associated with the common cold. LTRA administration did not reduce the risk of wheezing attacks requiring systemic steroids. Therefore, there is not enough evidence to support the recommendation of using LTRA for episodic viral wheeze in children.</p>

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