Methotrexate Associated Lymphoproliferative Disorders Arising in the Buccal Mucosa: A Case Report

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  • SHIMIZU Hiroyuki
    Department of Dentistry and Oral Surgery, Keio University School of Medicine
  • ISHII Shutaro
    Department of Dentistry and Oral Surgery, Keio University School of Medicine
  • SATO Hidekazu
    Department of Dentistry and Oral Surgery, Keio University School of Medicine
  • FURUSAWA Haruka
    Department of Dentistry and Oral Surgery, Keio University School of Medicine
  • KATO Shin
    Department of Dentistry and Oral Surgery, Keio University School of Medicine
  • NAKAGAWA Taneaki
    Department of Dentistry and Oral Surgery, Keio University School of Medicine
  • TSUNODA Kazuyuki
    Department of Dentistry and Oral Surgery, Keio University School of Medicine

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Other Title
  • 頬粘膜に発症したメトトレキサート関連リンパ増殖性疾患の1例
  • 症例報告 頬粘膜に発症したメトトレキサート関連リンパ増殖性疾患の1例
  • ショウレイ ホウコク ホオ ネンマク ニ ハッショウ シタ メトトレキサート カンレン リンパ ゾウショクセイ シッカン ノ 1レイ

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Abstract

Methotrexate-associated lymphoproliferative disorder （MTX-LPD）, which may develop in the oral cavity, is known to be associated with the administration of methotrexate. We herein report a case of MTX-LPD that developed in the buccal mucosa. The patient was a 64-year-old woman who had undergone long-term methotrexate treatment for rheumatoid arthritis and who complained of ulcer formation in the bilateral buccal mucosa. The pathological diagnosis was diffuse large B-cell lymphoma with Epstein-Barr virus-positive cells. The lesions improved following the withdrawal of methotrexate. The development of MTX-LPD in the buccal mucosa is very rare.

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