Synthetic tissue engineering: Programming multicellular self-organization by designing customized cell-cell communication

• Toda Satoshi

  WPI Nano Life Science Institute, Kanazawa University

抄録

Cells communicate with each other to organize multicellular collective systems and assemble complex, elaborate tissue structures by themselves during development. Despite intensive biological studies, what kind of cell-cell communication can sufficiently drive self-organization of specific tissue architectures remain unclear. Thanks to recent advances on genetic engineering technologies, synthetic biologists start to build customized cell-cell communication with user-defined signal input and gene expression output to program multicellular behaviors using mammalian systems. This review article introduces how we can design and engineer customized cell-cell communication to program synthetic self-organizing multicellular structures. Creating tissue formation processes with synthetic genetic programs will help understanding of fundamental principles of how genetic programs drive tissue self-organization and provide new capabilities on tissue engineering for cell-based regenerative therapy applications.

収録刊行物

• Biophysics and Physicobiology

  Biophysics and Physicobiology 17 (0), 42-50, 2020

  一般社団法人 日本生物物理学会

キーワード

• synthetic biology
• cell engineering
• cell-cell communication
• self-organization
• tissue engineering

詳細情報

• CRID: 1390848250127812992
• NII論文ID: 130007872428
• DOI: 10.2142/biophysico.bsj-2020002
• ISSN: 21894779
• Web Site: https://www.jstage.jst.go.jp/article/biophysico/17/0/17_BSJ-2020002/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2022006342
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
  • KAKEN
• 抄録ライセンスフラグ: 使用不可