Exposure to cold airflow alters skin pH and epidermal filaggrin degradation products in children with atopic dermatitis

• Jung Minyoung

  Department of Pediatrics, Kosin University Gospel Hospital, Kosin University School of Medicine

• Kim Insung

  Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine

• Lee Ji Young

  Department of Pediatrics, Hallym University Hangang Sacred Heart Hospital

• Kim Hyun Mi

  Environmental Health Center for Atopic Diseases, Samsung Medical Center

• Kwon Mijeong

  Environmental Health Center for Atopic Diseases, Samsung Medical Center

• Kim Minjeong

  Graduate School of Pharmaceutical Sciences, College of Pharmacy, Ewha Womans University

• Lim Kyung-Min

  Graduate School of Pharmaceutical Sciences, College of Pharmacy, Ewha Womans University

• Kim Peter S.

  Department of Chemistry, Colorado College

• Ahn Kangmo

  Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine Environmental Health Center for Atopic Diseases, Samsung Medical Center

• Kim Jihyun

  Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine Environmental Health Center for Atopic Diseases, Samsung Medical Center

Abstract

Background: We aimed to evaluate the influence of cold airflow from the air conditioner on skin barrier function and filaggrin degradation products (FDPs) in children with atopic deramtitis (AD). Methods: In a case-control study, 28 children with AD and 12 normal children without AD were exposed to one of two air conditioner modes (conventional or wind-free) for 2 h. Skin temperature, transepidermal water loss (TEWL), and skin pH were measured on right cheek and forearm at pre- and post-exposure time points. We also measured filaggrin and FDPs from the volar surface of the forearm. Results: In AD patients, skin temperature on the forearm decreased after exposure to the conventional and wind-free modes (P < 0.001 and P = 0.026), and TEWL on the cheek and the forearm decreased in the wind-free mode (P = 0.037 and 0.002). Skin pH on the cheek increased only after exposure to the conventional mode in AD group (P = 0.002). However, no changes in TEWL and skin pH were found after exposure to either the conventional or the wind-free mode in the control group. In AD children, the levels of pyrrolidone carboxylic acid (PCA) and cis-urocanic acid (UCA) were reduced only after exposure to the conventional mode (all P = 0.033). The percent changes of PCA and cis-UCA were higher in the AD group than those in the control group after exposure to conventional mode (P = 0.029 and 0.046). Conclusions: Skin barrier function in children with AD may be altered by the exposure to cold airflow from a conventional air conditioner.

Journal

• Allergology International

  Allergology International 69 (3), 429-436, 2020

  Japanese Society of Allergology

Keywords

• Air movements
• Atopic dermatitis
• Environmental impact
• Filaggrin
• Wind

Details

• CRID: 1390003825200020352
• NII Article ID: 130007877720
• DOI: 10.1016/j.alit.2019.11.004
• ISSN: 14401592
• ISSN: 13238930
• Web Site: https://api.elsevier.com/content/article/PII:S1323893019301960?httpAccept=text/xml
• Web Site: https://api.elsevier.com/content/article/PII:S1323893019301960?httpAccept=text/plain
• Web Site: https://search.jamas.or.jp/link/ui/2021198019
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed