Fatty acid remodeling of glycerophospholipids and formation of arachidonic acid-containing bioactive lipid mediators

• Yamashita Atsushi

  Faculty of Pharma-Sciences, Teikyo University

Bibliographic Information

Other Title

• グリセロリン脂質の脂肪リモデリングと アラキドン酸含有生理活性脂質の産生

Abstract

Fatty acid remodeling systems for glycerophospholipids including acyl-CoA:lysophospholipid acyltransferases, and CoA-dependent or CoA-independent transacylation reactions are involved in the biosynthesis of the molecular species with different fatty acyl moieties and incorporation of arachidonic acid into phospholipids. Although various kind of acyltransferases have been cloned and characterized, the molecular mechanism of CoA-dependent or CoA-independent transacylation reactions has not been elucidated yet. In this article, recent progresses in acyltransferase research including the identification of the enzyme’s genes are described. In addition, the mechanisms of CoA-dependent or independent transacylation reactions are discussed. I also refer to the biosynthesis of arachidonic acid-containing lipid mediators during the processes of fatty acid remodeling of phospholipids.

Journal

• ADC Letter for Infectious Disease Control

  ADC Letter for Infectious Disease Control 7 (2), 60-65, 2020

  Asia International Institute of Infectiou Disease Control, Teikyo University

Details

• CRID: 1390285300179331712
• NII Article ID: 130007882240
• DOI: 10.20814/adc.7.2_60
• ISSN: 24240907
• ISSN: 21895171
• Text Lang: ja
• Data Source:
  • JaLC
  • CiNii Articles
• Abstract License Flag: Disallowed