Facile Synthesis of Kwakhurin, a Marker Compound of Pueraria mirifica and Its Quantitative NMR Analysis for Standardization as a Reagent
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- Tsuji Genichiro
- National Institute of Health Sciences
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- Yusa Masaaki
- National Institute of Health Sciences
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- Masada Sayaka
- National Institute of Health Sciences
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- Yokoo Hidetomo
- National Institute of Health Sciences Graduate School of Medical Life Science, Yokohama City University
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- Hosoe Junko
- National Institute of Health Sciences
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- Hakamatsuka Takashi
- National Institute of Health Sciences
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- Demizu Yosuke
- National Institute of Health Sciences Graduate School of Medical Life Science, Yokohama City University
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- Uchiyama Nahoko
- National Institute of Health Sciences
書誌事項
- タイトル別名
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- Facile Synthesis of Kwakhurin, a Marker Compound of <i>Pueraria mirifica</i> and Its Quantitative NMR Analysis for Standardization as a Reagent
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<p>The side effects of kwao keur dietary supplements (obtained from the tuberous root of Pueraria mirifica) have recently been reported by the Ministry of Health, Labour and Welfare, Japan. To control the quality of kwao keur products, its ingredients need to be maintained by characteristic marker compounds, such as miroestrol, deoxymiroestrol, and kwakhurin (KWA). In this study, we described the facile synthesis of KWA, a marker compound of P. mirifica. Our revised synthetic method produced KWA with shorter steps and higher yield than the reported method. Furthermore, the absolute purity of KWA was determined by quantitative NMR analysis for standardization as a reagent, and its purity was 92.62 ± 0.12%.</p>
収録刊行物
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- CHEMICAL & PHARMACEUTICAL BULLETIN
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CHEMICAL & PHARMACEUTICAL BULLETIN 68 (8), 797-801, 2020-08-01
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390848250133350912
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- NII論文ID
- 130007883280
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- NII書誌ID
- AA00602100
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- ISSN
- 13475223
- 00092363
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- NDL書誌ID
- 030547750
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- PubMed
- 32434998
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可