Redox State Control of Human Cytoglobin by Direct Electrochemical Method to Investigate Its Function in Molecular Basis

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  • Mie Yasuhiro
    Bioproduction Research Institute, National Institute of Advanced Industrial Science and Technology (AIST)
  • Takahashi Kyoka
    Bioproduction Research Institute, National Institute of Advanced Industrial Science and Technology (AIST)
  • Torii Ryo
    Graduate School of Pharmaceutical Sciences, Osaka University
  • Jingkai Shen
    Graduate School of Pharmaceutical Sciences, Osaka University
  • Tanaka Takumi
    Graduate School of Pharmaceutical Sciences, Osaka University
  • Sueyoshi Kenta
    Graduate School of Pharmaceutical Sciences, Osaka University
  • Tsujino Hirofumi
    Graduate School of Pharmaceutical Sciences, Osaka University
  • Yamashita Taku
    School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women’s University

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Abstract

<p>The direct electron transfer between human cytoglobin (Cygb) and the electrode surface, which would allow manipulating the oxidation states of the heme iron in Cygb, was first observed by immobilizing Cygb on a nanoporous gold (NPG) electrode via a carboxy-terminated alkanethiol. The voltammetric performances of the wild type and mutated Cygb-immobilized NPG electrodes were evaluated in the absence or presence of potential substrates. The obtained results demonstrated that the usefulness of the proposed method in understanding the function of Cygb in molecular basis.</p>

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