Structure-Activity Relationship of Anti-malarial Allylpyrocatechol Isolated from Piper betle
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- Tamura Satoru
- School of Pharmacy, Iwate Medical University Graduate School of Pharmaceutical Sciences, Osaka University
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- Miyoshi Akihito
- Graduate School of Pharmaceutical Sciences, Osaka University
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- Kawano Tomikazu
- School of Pharmacy, Iwate Medical University
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- Horii Toshihiro
- Research Institute for Microbial Diseases, Osaka University
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- Itagaki Sawako
- Research Institute for Microbial Diseases, Osaka University
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- Murakami Nobutoshi
- Graduate School of Pharmaceutical Sciences, Osaka University
書誌事項
- タイトル別名
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- Structure–Activity Relationship of Anti-malarial Allylpyrocatechol Isolated from <i>Piper betle</i>
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抄録
<p>Malaria disease remains a serious worldwide health problem. In South-East Asia, one of the malaria infection “hot-spots,” medicinal plants such as Piper betle have traditionally been used for the treatment of malaria, and allylpyrocatechol (1), a constituent of P. betle, has been shown to exhibit anti-malarial activities. In this study, we verified that 1 showed in vivo anti-malarial activity through not only intraperitoneal (i.p.) but also peroral (p.o.) administration. Additionally, some analogs of 1 were synthesized and the structure–activity relationship was analyzed to disclose the crucial sub-structures for the potent activity.</p>
収録刊行物
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- ＣＨＥＭＩＣＡＬ ＆ ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ ＢＵＬＬＥＴＩＮ
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ＣＨＥＭＩＣＡＬ ＆ ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ ＢＵＬＬＥＴＩＮ 68 (8), 784-790, 2020-08-01
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390003825203224576
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- NII論文ID
- 130007883290
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- NII書誌ID
- AA00602100
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- ISSN
- 13475223
- 00092363
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- NDL書誌ID
- 030547683
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- PubMed
- 32741921
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可
