Air-pressure-driven Separable Microdevice to Control the Anisotropic Curvature of Cell Culture Surface

• YAMASHITA Tadahiro

  Department of System Design Engineering, Keio University

• NISHINA Takuya

  Department of System Design Engineering, Keio University

• MATSUSHITA Ichiro

  Department of System Design Engineering, Keio University

• SUDO Ryo

  Department of System Design Engineering, Keio University

Bibliographic Information

Other Title

• Advancements in Instrumentation : Air-pressure-driven Separable Microdevice to Control the Anisotropic Curvature of Cell Culture Surface

Abstract

We report on a novel microdevice to tune the curvature of a cell-adhering surface by controlling the air-pressure and micro-slit. Human aortic smooth muscle cells were cultured on demi-cylindrical concaves formed on a microdevice. Their shape-adapting behavior could be tracked when the groove direction was changed to the orthogonal direction. This microdevice demonstrated live observation of cells responding to dynamic changes of the anisotropic curvature of the adhering surface and could serve as a new platform to pursue mechanobiology on curved surfaces.

Journal

• Analytical Sciences

  Analytical Sciences 36 (8), 1015-1019, 2020-08-10

  The Japan Society for Analytical Chemistry

Keywords

• Mechanobiology
• curvature
• cell adhesion
• smooth muscle cell
• orientation

Details

• CRID: 1390003825205098624
• NII Article ID: 130007886467
• NII Book ID: AA10500785
• DOI: 10.2116/analsci.20a001
• ISSN: 13482246
• ISSN: 09106340
• NDL BIB ID: 030563877
• PubMed: 32201406
• Web Site: http://id.ndl.go.jp/bib/030563877
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I030563877
• Web Site: https://link.springer.com/content/pdf/10.2116/analsci.20A001.pdf
• Web Site: https://link.springer.com/article/10.2116/analsci.20A001/fulltext.html
• Web Site: https://www.jstage.jst.go.jp/article/analsci/36/8/36_20A001/_pdf
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed