Effect of 16-week Outpatient Rehabilitation on Symptom Burden and Physical Function in a Patient with Plasmacytoma Diagnosed with Chemotherapyinduced Peripheral Neuropathy：A Case Report

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  • Makiura Daisuke
    Department of Rehabilitation, Kobe University Hospital
  • Saito Takashi
    Department of Rehabilitation, Kobe University Hospital Department of Community Health Sciences, Kobe University Graduate School of Health Sciences
  • Inoue Junichiro
    Department of Rehabilitation, Kobe University Hospital
  • Doi Hisayo
    Division of Nursing, Kobe University Hospital
  • Yakushijin Kimikazu
    Division of Medical Oncology and Hematology, Kobe University Hospital
  • Sakai Yoshitada
    Division of Physical Medicine and Rehabilitation, Kobe University Hospital

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Other Title
  • 化学療法誘発性末梢神経障害に対して16週間の外来リハビリテーション治療を実施し，症状緩和と身体機能改善が得られた1症例
  • 症例報告 化学療法誘発性末梢神経障害に対して16週間の外来リハビリテーション治療を実施し,症状緩和と身体機能改善が得られた1症例
  • ショウレイ ホウコク カガク リョウホウ ユウハツセイ マッショウ シンケイ ショウガイ ニ タイシテ 16シュウカン ノ ガイライ リハビリテーション チリョウ オ ジッシ シ,ショウジョウ カンワ ト シンタイ キノウ カイゼン ガ エラレタ 1 ショウレイ

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Abstract

<p>This case report describes the effect of exercise therapy on a patient with plasmacytoma diagnosed with chemotherapy-induced peripheral neuropathy (CIPN). A man in his mid 70s was diagnosed with plasmacytoma and received outpatient chemotherapy. He developed glove-and-stocking numbness and balance disorder and underwent 16-week multimodal exercise therapy consisting of resistance and balance training, and aerobic exercise. He attended one session per week of exercise therapy at a hospital under the supervision of a physical therapist and completed five sessions of home-based exercise. His symptoms and physical function were evaluated at baseline and after intervention using the Common Terminology Criteria for Adverse Events version 5.0 (CTCAE), Functional Assessment of Cancer Therapy-Neurotoxicity subscale (FACT-Ntx), modified Total Neuropathy Score (mTNS), Stand-up test, and Berg Balance Scale (BBS). After the 16-week intervention, clinician-assessed CIPN symptoms were stable (CTCAE：Grade 2 at baseline, Grade 2 after intervention), whereas patient-reported CIPN symptoms improved beyond the minimal clinically important difference (FACT-Ntx score increased from 22 to 29 points). Although the components of mTNS such as motor symptoms and strength improved, the total mTNS score remained stable. The Stand-up test and BBS scores improved, and better physical function led to improvements in activities of daily living. Thus, exercise therapy may effectively reduce the symptom burden and improve physical function in patients with CIPN.</p>

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