Towards the generation of human iPSC-derived hematopoietic stem cells

DOI
  • Abe Tomoyuki
    Open Science Laboratory, Center for Development of Advanced Medical Technology, Division of Regenerative Medicine, Center for Molecular Medicine, Jichi Medical University
  • Hanazono Yutaka
    Open Science Laboratory, Center for Development of Advanced Medical Technology, Division of Regenerative Medicine, Center for Molecular Medicine, Jichi Medical University

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Other Title
  • ヒトiPS細胞由来造血幹細胞の作成を目指して

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Abstract

<p>Generation of hematopoietic stem cells (HSCs) from embryonic stem cells (ESCs) or induced pluripotent stem cells (iPSCs) has been a long-standing, challenging goal of hematology. In this review, current advances toward the goal utilizing various in-vitro differentiation techniques and animal in-vivo microenvironments will be summarized. In addition, we will introduce our unique method of sheep in-utero transplantation targeting a fetal liver as an in vivo microenvironment for hematopoietic engraftment.</p>

Journal

  • Organ Biology

    Organ Biology 27 (2), 167-172, 2020

    The Japan Society for Organ Preservation and Biology

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