A Novel Treatment for Arrhythmias via the Control of the Degradation of Ion Channel Proteins

• Miake Junichiro

  Division of Pharmacology, Department of Pathophysiological and Therapeutic Science, School of Medicine, Faculty of Medicine, Tottori University, Yonago 683-8503, Japan

Abstract

Although there are many reports on the regulation of ion channel expression in transcription and translation, few drugs have been studied to influence post-translational modification of ion channel proteins. The Kv1.5 channel is a potassium ion channel expressed in atrial muscle, belongs to the voltage-gated K⁺ channel superfamily, and forms an ultrarapid delayed rectifier potassium ion current. It is important to understand the fate of these channel proteins, as cardiac Kv1.5 mutations can cause arrhythmias. Disruption of quantitative and qualitative control mechanisms of channels leads to stagnation and degradation of intracellular channel proteins. As a result, ion channel proteins are not transported to the cell membrane and are involved in the development of atrial fibrillation. This review takes the Kv1.5 channel as an example and focuses on the degradation mechanism of ion channel proteins, and discusses its application to the treatment of arrhythmia by drugs that control the mechanism of ion channel protein degradation.

Journal

• Yonago Acta Medica

  Yonago Acta Medica 63 (3), 146-153, 2020

  Tottori University Medical Press

Keywords

• arrhythmia
• chaperon
• degradation
• ion channel
• trafficking

Details

• CRID: 1390848250136526976
• NII Article ID: 130007888757
• NII Book ID: AA00892882
• DOI: 10.33160/yam.2020.08.002
• ISSN: 13468049
• ISSN: 05135710
• Web Site: https://repository.lib.tottori-u.ac.jp/records/4731
• Web Site: https://www.jstage.jst.go.jp/article/yam/63/3/63_2020.08.002/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2021219099
• Text Lang: en
• Data Source:
  • JaLC
  • IRDB
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed