身体活動の持続性に着目した認知機能低下に関する縦断研究

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  • A Longitudinal Study on Cognitive Decline Judgement based on Duration of Physical Activities
  • シンタイ カツドウ ノ ジゾクセイ ニ チャクモク シタ ニンチ キノウ テイカ ニ カンスル ジュウダン ケンキュウ

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With regard to the decline in cognitive function associated with the aging of the elderly individuals, we newly find a feature value that is captured by the change in the amount of activity, and obtain the accuracy of the judgment. In other words, we propose a feature quantity “1 / T index” focusing on the duration T of activity, and determine the accuracy of cognitive decline in individuals. Specifically, the difference between the 1 / T index value of an individual 4 years ago and the same index value 4 years later is compared with a preset difference threshold. The target data are activity data and cognitive function evaluation values (MMSE scores) obtained from elderly individuals before and after aging for 4 years. The group that was initially cognitive healthy (with an MMSE value of 27 or higher) and an average of 75 years old is divided into two groups. One is the cognitive decline group that became cognitive unhealthy after 4 years (MMSE value of 26 or lower), and the other is the non-decline group that remained cognitive healthy after 4 years. Then, we calculate the difference between the 1 / T index values of each group before and after 4 years. As a result of ROC analysis, AUC value 0.67 was confirmed. In addition, the most appropriate difference threshold of 0.006 was obtained, and as a result of the judgment of cognitive decline, sensitivity of 64.3% and specificity of 75.0% were confirmed.

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