Effect of Rubbing on the Distribution of Topically Applied Drugs into the Hair Follicles
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- Abe Akinari
- Graduate School of Pharmaceutical Sciences, Josai University Research & Development Headquarters Self-Medication, Taisho Pharmaceutical Co., Ltd.
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- Suzuki Hiromichi
- Graduate School of Pharmaceutical Sciences, Josai University
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- Saito Miyuki
- Graduate School of Pharmaceutical Sciences, Josai University
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- Todo Hiroaki
- Graduate School of Pharmaceutical Sciences, Josai University
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- Sugibayashi Kenji
- Graduate School of Pharmaceutical Sciences, Josai University
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<p>Rubbing actions are often conducted to apply topical formulations onto the skin. Although rubbing was found to increase the skin permeation of drugs, few reports have revealed whether rubbing enhanced either drug permeation through the stratum corneum (SC) or hair follicles (HFs) pathways, or through both. In the present study, we investigated the effects of rubbing on caffeine (CAF) distribution in the SC and HFs. The effect of rubbing direction on the skin penetration of CAF was also investigated. The skin concentration of CAF and its cumulative permeation amount were increased clearly by rubbing. More than six times higher CAF concentrations in the viable epidermis and dermis were observed 5 min after rubbing application compared with no rubbing. On the other hand, slightly increased CAF concentrations were observed in the SC, suggesting that CAF was delivered through the HF pathway by rubbing. Rubbing against the natural hair direction provided the highest skin permeation as well as skin concentrations. Changes in the morphology of the HF opening area might be related to the enhancement effect. These results may provide useful information to understand the effect of rubbing on the skin permeation of applied drugs.</p>
収録刊行物
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- CHEMICAL & PHARMACEUTICAL BULLETIN
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CHEMICAL & PHARMACEUTICAL BULLETIN 68 (9), 832-836, 2020-09-01
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390285300186447872
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- NII論文ID
- 130007893865
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- NII書誌ID
- AA00602100
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- ISSN
- 13475223
- 00092363
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- NDL書誌ID
- 030605881
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- PubMed
- 32879223
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 使用不可