Whole body autoradiography in rats after percutaneous administration of [14C]2-chloroaniline

• YANAGIBA Yukie

  National Institute of Occupational Safety and Health

• TOYOOKA Tatsushi

  National Institute of Occupational Safety and Health

• WANG Rui-Sheng

  National Institute of Occupational Safety and Health

• KODA Shigeki

  National Institute of Occupational Safety and Health

Bibliographic Information

Other Title

• ラットへのオルト-クロロアニリン経皮投与後の全身オートラジオグラフィと尿中排泄に関する検討

Abstract

Recentrly, a high incidence rate of bladder cancer were reported among employees in a chemical factory , where using aromatic amines. We investigated the whole-animal biodistribution of OCA using autoradiography after percutaneous administration in rats. [¹⁴C]OCA was percutaneously administered for 8 and 24 hours by covering with a lint cloth soaked in [¹⁴C]OCA solution at a dose of 50 mg/748kBq/4 mL/kg. After the completion of administration, and whole-body autoradioluminograms were prepared. The bladder had high level of radioactivity at 8 hr, indicating that OCA can be absorbed from the skin and transferred to bladder. The urinary excretion reached 86% of administered OCA during 8-24 hours.

Journal

• Annual Meeting of the Japanese Society of Toxicology

  Annual Meeting of the Japanese Society of Toxicology 47.1 (0), P-116-, 2020

  The Japanese Society of Toxicology

Details

• CRID: 1390285697591451904
• NII Article ID: 130007898203
• DOI: 10.14869/toxpt.47.1.0_p-116
• Text Lang: ja
• Data Source:
  • JaLC
  • CiNii Articles
• Abstract License Flag: Disallowed